Pituitary surgery for Cushing’s disease

Background Surgery is currently the first-line treatment of Cushing’s disease. Surgery for Cushing’s patients requires technical specificity, especially if no adenoma is identified on dedicated preoperative pituitary MRI. Method From 2006 to 2020, 683 patients with Cushing’s disease were operated on with a mononostril endoscopic endonasal approach by the same two senior neurosurgeons. Here, we report the particularities of this challenging surgery. Conclusion A rigorous and planned surgical strategy avoids the pitfalls of Cushing’s disease surgery and leads to a high rate of endocrine remission.