Cell cycle control in cancer

Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells. Cell cycle checkpoints operate as DNA surveillance mec...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2022-01, Vol.23 (1), p.74-88
Hauptverfasser:	Matthews, Helen K., Bertoli, Cosetta, de Bruin, Robertus A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1427/2567 631/337/641/2187 631/67 631/67/1244 631/80/641 Animals Biochemistry Biomedical and Life Sciences Cancer Cancer Research Cell Biology Cell cycle Cell Cycle Checkpoints Cell death Cell division Cell viability Damage prevention Deoxyribonucleic acid Developmental Biology DNA DNA damage DNA Damage - genetics DNA Replication - genetics Humans Life Sciences Mutation Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy Oncogenes Regulatory mechanisms (biology) Review Article Spindle Apparatus - metabolism Stem Cells
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