Upregulation of VDR-associated lncRNAs in Schizophrenia
Vitamin D receptor (VDR) signaling has been found to contribute to the pathology of numerous neuropsychiatric diseases including schizophrenia. Notably, VDR signaling has a functional relationship with many long non-coding RNAs (lncRNAs) such as SNHG6 , LINC00346 and LINC00511 . We calculated expres...
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| Veröffentlicht in: | Journal of molecular neuroscience 2022-02, Vol.72 (2), p.239-245 |
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| container_title | Journal of molecular neuroscience |
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| creator | Ghafouri-Fard, Soudeh Eghtedarian, Reyhane Seyedi, Motahareh Pouresmaeili, Farkhondeh Arsang-Jang, Shahram Taheri, Mohammad |
| description | Vitamin D receptor (VDR) signaling has been found to contribute to the pathology of numerous neuropsychiatric diseases including schizophrenia. Notably, VDR signaling has a functional relationship with many long non-coding RNAs (lncRNAs) such as
SNHG6
,
LINC00346
and
LINC00511
. We calculated expression of these lncRNAs in the venous blood of patients with schizophrenia versus healthy individuals. Expression of
SNHG6
was significantly higher in cases versus controls (posterior beta = 0.552, adjusted
P
value |
| doi_str_mv | 10.1007/s12031-021-01901-y |
| format | Article |
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SNHG6
,
LINC00346
and
LINC00511
. We calculated expression of these lncRNAs in the venous blood of patients with schizophrenia versus healthy individuals. Expression of
SNHG6
was significantly higher in cases versus controls (posterior beta = 0.552, adjusted
P
value < 0.0001). This pattern of expression was detected in both men (posterior beta = 0.556, adjusted
P
value < 0.0001) and women (posterior beta = 0.31, adjusted
P
value = 0.005). Expression of
LINC00346
was also higher in cases versus controls (posterior beta = 0.497, adjusted
P
value < 0.0001) and in distinct sex-based comparisons (posterior beta = 0.451, adjusted
P
value = 0.009 among men and posterior beta = 0.214,
P
value = 0.004 among women). Expression of
LINC00511
was higher in cases versus controls (posterior beta = 0.318, adjusted
P
value = 0.01). While sex-based comparisons revealed significant difference in expression of
LINC00511
among female subgroups (posterior beta = 0.424, adjusted
P
value = 0.016), such comparison showed no difference among male cases and male controls (adjusted
P
value = 0.295). The expression levels of
SNHG6
distinguished patients with schizophrenia from controls, with AUC = 0.932.
LINC00346
and
LINC00511
distinguished between the two groups with AUC values of 0.795 and 0.706, respectively. Therefore, these lncRNAs might be used as markers for schizophrenia.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-021-01901-y</identifier><identifier>PMID: 34499334</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Female ; Humans ; Male ; Men ; Mental disorders ; Neurochemistry ; Neurology ; Neurosciences ; Non-coding RNA ; Proteomics ; Receptors, Calcitriol - genetics ; Receptors, Calcitriol - metabolism ; RNA, Long Noncoding - metabolism ; Schizophrenia ; Schizophrenia - genetics ; Sex ; Signal Transduction ; Signaling ; Subgroups ; Transcriptional Activation ; Up-Regulation ; Vitamin D ; Vitamin D receptors ; Women</subject><ispartof>Journal of molecular neuroscience, 2022-02, Vol.72 (2), p.239-245</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-cd41e2ed5df0156c9e511878f38e4c0bee0837e9cc3e93d0e99a7b9c6a897ae73</citedby><cites>FETCH-LOGICAL-c375t-cd41e2ed5df0156c9e511878f38e4c0bee0837e9cc3e93d0e99a7b9c6a897ae73</cites><orcidid>0000-0001-8381-0591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-021-01901-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-021-01901-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34499334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghafouri-Fard, Soudeh</creatorcontrib><creatorcontrib>Eghtedarian, Reyhane</creatorcontrib><creatorcontrib>Seyedi, Motahareh</creatorcontrib><creatorcontrib>Pouresmaeili, Farkhondeh</creatorcontrib><creatorcontrib>Arsang-Jang, Shahram</creatorcontrib><creatorcontrib>Taheri, Mohammad</creatorcontrib><title>Upregulation of VDR-associated lncRNAs in Schizophrenia</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>Vitamin D receptor (VDR) signaling has been found to contribute to the pathology of numerous neuropsychiatric diseases including schizophrenia. Notably, VDR signaling has a functional relationship with many long non-coding RNAs (lncRNAs) such as
SNHG6
,
LINC00346
and
LINC00511
. We calculated expression of these lncRNAs in the venous blood of patients with schizophrenia versus healthy individuals. Expression of
SNHG6
was significantly higher in cases versus controls (posterior beta = 0.552, adjusted
P
value < 0.0001). This pattern of expression was detected in both men (posterior beta = 0.556, adjusted
P
value < 0.0001) and women (posterior beta = 0.31, adjusted
P
value = 0.005). Expression of
LINC00346
was also higher in cases versus controls (posterior beta = 0.497, adjusted
P
value < 0.0001) and in distinct sex-based comparisons (posterior beta = 0.451, adjusted
P
value = 0.009 among men and posterior beta = 0.214,
P
value = 0.004 among women). Expression of
LINC00511
was higher in cases versus controls (posterior beta = 0.318, adjusted
P
value = 0.01). While sex-based comparisons revealed significant difference in expression of
LINC00511
among female subgroups (posterior beta = 0.424, adjusted
P
value = 0.016), such comparison showed no difference among male cases and male controls (adjusted
P
value = 0.295). The expression levels of
SNHG6
distinguished patients with schizophrenia from controls, with AUC = 0.932.
LINC00346
and
LINC00511
distinguished between the two groups with AUC values of 0.795 and 0.706, respectively. Therefore, these lncRNAs might be used as markers for schizophrenia.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Men</subject><subject>Mental disorders</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Non-coding RNA</subject><subject>Proteomics</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Receptors, Calcitriol - metabolism</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Sex</subject><subject>Signal Transduction</subject><subject>Signaling</subject><subject>Subgroups</subject><subject>Transcriptional Activation</subject><subject>Up-Regulation</subject><subject>Vitamin D</subject><subject>Vitamin D receptors</subject><subject>Women</subject><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxhQJBaWgM-OY3usyqdUgVQ-Vst1LpAqTYqdDOXXYygfEgPD6YZ77r3TQ8gh0FOgVJ4FYJRDSlks0BTS9RYZghA6BcjzbTKkSotU5TofkL0QFjSSGahdMuBZpjXn2ZDIx5XH5762XdU2SVsmT-ez1IbQusp2WCR142a345BUTXLvXqq3dvXisansPtkpbR3w4KuPyOPlxcPkOp3eXd1MxtPUcSm61BUZIMNCFCUFkTuNAkBJVXKFmaNzRKq4RO0cR80LilpbOdcut0pLi5KPyMkmd-Xb1x5DZ5ZVcFjXtsG2D4YJCVRwwfOIHv9BF23vm_idYTlTFLKMsUixDeV8G4LH0qx8tbR-bYCaD61mo9VEWeZTq1nHpaOv6H6-xOJn5dtjBPgGCHHUPKP_vf1P7DsNKoHW</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Ghafouri-Fard, Soudeh</creator><creator>Eghtedarian, Reyhane</creator><creator>Seyedi, Motahareh</creator><creator>Pouresmaeili, Farkhondeh</creator><creator>Arsang-Jang, Shahram</creator><creator>Taheri, Mohammad</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8381-0591</orcidid></search><sort><creationdate>20220201</creationdate><title>Upregulation of VDR-associated lncRNAs in Schizophrenia</title><author>Ghafouri-Fard, Soudeh ; Eghtedarian, Reyhane ; Seyedi, Motahareh ; Pouresmaeili, Farkhondeh ; Arsang-Jang, Shahram ; Taheri, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-cd41e2ed5df0156c9e511878f38e4c0bee0837e9cc3e93d0e99a7b9c6a897ae73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Men</topic><topic>Mental disorders</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Non-coding RNA</topic><topic>Proteomics</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Receptors, Calcitriol - metabolism</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>Sex</topic><topic>Signal Transduction</topic><topic>Signaling</topic><topic>Subgroups</topic><topic>Transcriptional Activation</topic><topic>Up-Regulation</topic><topic>Vitamin D</topic><topic>Vitamin D receptors</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghafouri-Fard, Soudeh</creatorcontrib><creatorcontrib>Eghtedarian, Reyhane</creatorcontrib><creatorcontrib>Seyedi, Motahareh</creatorcontrib><creatorcontrib>Pouresmaeili, Farkhondeh</creatorcontrib><creatorcontrib>Arsang-Jang, Shahram</creatorcontrib><creatorcontrib>Taheri, Mohammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghafouri-Fard, Soudeh</au><au>Eghtedarian, Reyhane</au><au>Seyedi, Motahareh</au><au>Pouresmaeili, Farkhondeh</au><au>Arsang-Jang, Shahram</au><au>Taheri, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of VDR-associated lncRNAs in Schizophrenia</atitle><jtitle>Journal of molecular neuroscience</jtitle><stitle>J Mol Neurosci</stitle><addtitle>J Mol Neurosci</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>72</volume><issue>2</issue><spage>239</spage><epage>245</epage><pages>239-245</pages><issn>0895-8696</issn><eissn>1559-1166</eissn><abstract>Vitamin D receptor (VDR) signaling has been found to contribute to the pathology of numerous neuropsychiatric diseases including schizophrenia. Notably, VDR signaling has a functional relationship with many long non-coding RNAs (lncRNAs) such as
SNHG6
,
LINC00346
and
LINC00511
. We calculated expression of these lncRNAs in the venous blood of patients with schizophrenia versus healthy individuals. Expression of
SNHG6
was significantly higher in cases versus controls (posterior beta = 0.552, adjusted
P
value < 0.0001). This pattern of expression was detected in both men (posterior beta = 0.556, adjusted
P
value < 0.0001) and women (posterior beta = 0.31, adjusted
P
value = 0.005). Expression of
LINC00346
was also higher in cases versus controls (posterior beta = 0.497, adjusted
P
value < 0.0001) and in distinct sex-based comparisons (posterior beta = 0.451, adjusted
P
value = 0.009 among men and posterior beta = 0.214,
P
value = 0.004 among women). Expression of
LINC00511
was higher in cases versus controls (posterior beta = 0.318, adjusted
P
value = 0.01). While sex-based comparisons revealed significant difference in expression of
LINC00511
among female subgroups (posterior beta = 0.424, adjusted
P
value = 0.016), such comparison showed no difference among male cases and male controls (adjusted
P
value = 0.295). The expression levels of
SNHG6
distinguished patients with schizophrenia from controls, with AUC = 0.932.
LINC00346
and
LINC00511
distinguished between the two groups with AUC values of 0.795 and 0.706, respectively. Therefore, these lncRNAs might be used as markers for schizophrenia.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34499334</pmid><doi>10.1007/s12031-021-01901-y</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8381-0591</orcidid></addata></record> |
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| issn | 0895-8696 1559-1166 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Cell Biology Female Humans Male Men Mental disorders Neurochemistry Neurology Neurosciences Non-coding RNA Proteomics Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism RNA, Long Noncoding - metabolism Schizophrenia Schizophrenia - genetics Sex Signal Transduction Signaling Subgroups Transcriptional Activation Up-Regulation Vitamin D Vitamin D receptors Women |
| title | Upregulation of VDR-associated lncRNAs in Schizophrenia |
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