Upregulation of VDR-associated lncRNAs in Schizophrenia

Upregulation of VDR-associated lncRNAs in Schizophrenia

Vitamin D receptor (VDR) signaling has been found to contribute to the pathology of numerous neuropsychiatric diseases including schizophrenia. Notably, VDR signaling has a functional relationship with many long non-coding RNAs (lncRNAs) such as SNHG6 , LINC00346 and LINC00511 . We calculated expres...

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Veröffentlicht in:Journal of molecular neuroscience 2022-02, Vol.72 (2), p.239-245
Hauptverfasser: Ghafouri-Fard, Soudeh, Eghtedarian, Reyhane, Seyedi, Motahareh, Pouresmaeili, Farkhondeh, Arsang-Jang, Shahram, Taheri, Mohammad
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Female
Humans
Male
Men
Mental disorders
Neurochemistry
Neurology
Neurosciences
Non-coding RNA
Proteomics
Receptors, Calcitriol - genetics
Receptors, Calcitriol - metabolism
RNA, Long Noncoding - metabolism
Schizophrenia
Schizophrenia - genetics
Sex
Signal Transduction
Signaling
Subgroups
Transcriptional Activation
Up-Regulation
Vitamin D
Vitamin D receptors
Women
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Zusammenfassung:Vitamin D receptor (VDR) signaling has been found to contribute to the pathology of numerous neuropsychiatric diseases including schizophrenia. Notably, VDR signaling has a functional relationship with many long non-coding RNAs (lncRNAs) such as SNHG6 , LINC00346 and LINC00511 . We calculated expression of these lncRNAs in the venous blood of patients with schizophrenia versus healthy individuals. Expression of SNHG6 was significantly higher in cases versus controls (posterior beta = 0.552, adjusted P value 
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-021-01901-y