Associations Between Plasma Growth and Differentiation Factor-15 with Aging Phenotypes in Muscle, Adipose Tissue, and Bone

Growth and differentiation factor 15 (GDF-15) is associated with muscle, fat, and bone metabolism; however, this association has not been well characterized. Plasma GDF-15, appendicular skeletal muscle mass (ASM), fat mass (FM), and bone mineral density (BMD) were measured in 146 postmenopausal wome...

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Veröffentlicht in:	Calcified tissue international 2022-02, Vol.110 (2), p.236-243
Hauptverfasser:	Lee, Seung Hun, Lee, Jee Yang, Lim, Kyeong-Hye, Lee, Young-Sun, Koh, Jung-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue Aging Biochemistry Biomedical and Life Sciences Body Composition Body fat Body mass index Bone and Bones Bone Density Bone growth Bone mass Bone mineral density Bone turnover Cell Biology Endocrinology Fat metabolism Female Femur Growth Differentiation Factor 15 - blood Humans Life Sciences Muscle, Skeletal Obesity Original Research Orthopedics Phenotype Phenotypes Post-menopause Postmenopause Sarcopenia Sarcopenia - pathology Skeletal muscle
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Zusammenfassung:	Growth and differentiation factor 15 (GDF-15) is associated with muscle, fat, and bone metabolism; however, this association has not been well characterized. Plasma GDF-15, appendicular skeletal muscle mass (ASM), fat mass (FM), and bone mineral density (BMD) were measured in 146 postmenopausal women. GDF-15 levels were higher in subjects with low Body Mass Index (BMI)-adjusted ASM than in those without (median [interquartile range] 831.3 [635.4–1011.4] vs. 583.8 [455.8–771.1] pg/mL, p = 0.018). The GDF-15 level was inversely correlated with BMI-adjusted ASM ( r = − 0.377, p
ISSN:	0171-967X 1432-0827
DOI:	10.1007/s00223-021-00912-6