The role of oxidative stress and haematological parameters in relapsing-remitting multiple sclerosis in Kurdish population
•To find the role of oxidative stress in relapsing-remitting multiple sclerosis (RRMS) in Kurdish population.•To detect some major defects in haematological profiles in the RRMS.•To explore the disturbance of immunological parameters in the RRMS.•The utilization of Cu+2 supplement could be used as a...
Gespeichert in:
Veröffentlicht in: | Multiple sclerosis and related disorders 2021-11, Vol.56, p.103228-103228, Article 103228 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | •To find the role of oxidative stress in relapsing-remitting multiple sclerosis (RRMS) in Kurdish population.•To detect some major defects in haematological profiles in the RRMS.•To explore the disturbance of immunological parameters in the RRMS.•The utilization of Cu+2 supplement could be used as an effective modality in RRMS patients.
Multiple sclerosis (MS), as a neurodegenerative disorder, exhibits inflammation and oxidative stress hallmarks.
The research aims to know any disturbances in haematological parameters and antioxidant system of relapsing-remitting multiple sclerosis (RRMS) patients in the Kurdish population.
A case-control research meeting following the McDonald criterion was conducted on 100 RRMS patients and 100 controls.
Lipid peroxidation products of malondialdehyde (MDA), erythrocyte sedimentation rate (ESR), and total leucocyte counts (TLCs) were increased significantly, but copper (Cu+2) and superoxide dismutase (SOD) were decreased significantly while nitric oxide metabolites (NOx) and lymphocyte were not changed significantly if compared with that of controls.
Findings from our study revealed that some defects were detected in haematological profiles in the Kurdish population and disturbance of immunological parameters. In addition, the utilization of Cu+2 supplement as an effective modality for RRMS patients may be beneficial. |
---|---|
ISSN: | 2211-0348 2211-0356 |
DOI: | 10.1016/j.msard.2021.103228 |