Trust your gut: an early life lesson for T cells

Trust your gut: an early life lesson for T cells

Zegarra-Ruiz et al. demonstrate that gut microbe-specific T cells are selected within the thymus exclusively during early life in mice. This selection is dependent on CX3CR1+ dendritic cells migrating from the gut carrying bacterially derived antigens into the thymus. This offers new insight into ho...

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Veröffentlicht in:Trends in immunology 2021-10, Vol.42 (10), p.844-845
1. Verfasser: Cowan, Jennifer E.
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Cancer
Cell migration
CX3CR1 protein
Dendritic cells
E coli
Immune system
Inflammatory bowel disease
Intestinal microflora
Lymphocytes
Lymphocytes T
Medical research
Microbiota
Peptides
Salmonella
Thymus
Thymus gland
Weaning
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Zusammenfassung:Zegarra-Ruiz et al. demonstrate that gut microbe-specific T cells are selected within the thymus exclusively during early life in mice. This selection is dependent on CX3CR1+ dendritic cells migrating from the gut carrying bacterially derived antigens into the thymus. This offers new insight into how gut microbiota influence T cell development.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2021.08.010