(1-Selenocyanatoethyl)benzene: A Selenocyanation Reagent for Site-Selective Selenocyanation of Inert Alkyl C(sp3)–H Bonds

(1-Selenocyanatoethyl)benzene: A Selenocyanation Reagent for Site-Selective Selenocyanation of Inert Alkyl C(sp3)–H Bonds

A new, simple, yet easily accessible, (1-selenocyanatoethyl)­benzene has been designed and applied as a SeCN group transfer reagent for selenocyanation of aliphatic C­(sp3)–H bonds for the first time. This protocol is featured with mild reaction conditions and wide substrate scope. Control experimen...

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Veröffentlicht in:Organic letters 2021-09, Vol.23 (18), p.7156-7160
Hauptverfasser: Yu, Fei, Li, Chuang, Wang, Chuangye, Zhang, Hongwei, Cao, Zhong-Yan
Format: Artikel
Sprache:eng
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Zusammenfassung:A new, simple, yet easily accessible, (1-selenocyanatoethyl)­benzene has been designed and applied as a SeCN group transfer reagent for selenocyanation of aliphatic C­(sp3)–H bonds for the first time. This protocol is featured with mild reaction conditions and wide substrate scope. Control experiments reveal that a radical-group transfer mechanism might be involved.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c02564