Four New Triterpenoid Saponins from the Root of Ilex centrochinensis

One new siaresinolic acid saponin (1) and three new rotundic acid saponins (2–4) were isolated from the roots of Ilex centrochinensis. Their structures were confirmed by detailed analysis of standard spectroscopic data (IR, MS, 1D and 2D NMR). Compounds 1–4 exhibited anti‐inflammatory activity by in...

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Veröffentlicht in:	Chemistry & biodiversity 2021-11, Vol.18 (11), p.e2100343-n/a
Hauptverfasser:	Yang, Hang, Lu, Yan‐Xia, Shi, Yu, Deng, Xue‐Ying, Yi, Ying‐Tao, Li, Lu‐Jun, Hu, Ze‐Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Hep G2 Cells Humans Ilex - chemistry Ilex centrochinensis Inflammation Lipids Lipids - antagonists & inhibitors Lipopolysaccharides Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Mice Nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis NMR Nuclear magnetic resonance Oleic acid Plant Roots - chemistry RAW 264.7 Cells Saponins Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology structural elucidation Triglycerides Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoid saponins
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Zusammenfassung:	One new siaresinolic acid saponin (1) and three new rotundic acid saponins (2–4) were isolated from the roots of Ilex centrochinensis. Their structures were confirmed by detailed analysis of standard spectroscopic data (IR, MS, 1D and 2D NMR). Compounds 1–4 exhibited anti‐inflammatory activity by inhibiting nitric oxide production in a lipopolysaccharide‐induced RAW264.7 cell inflammatory model. However, they showed no significant lipid‐lowering activity against the production of triglycerides in the lipid‐accumulation model of HepG2 cells induced by oleic acid.
ISSN:	1612-1872 1612-1880
DOI:	10.1002/cbdv.202100343