Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

One month after the implantation of biodegradable-polymer sirolimus-eluting coronary stents, patients at high bleeding risk were randomly assigned to stop dual antiplatelet therapy or to continue it for at least 2 additional months. At 1 year, 1 month of DAPT was noninferior to the longer treatment...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-10, Vol.385 (18), p.1643-1655
Hauptverfasser:	Valgimigli, Marco, Frigoli, Enrico, Heg, Dik, Tijssen, Jan, Jüni, Peter, Vranckx, Pascal, Ozaki, Yukio, Morice, Marie-Claude, Chevalier, Bernard, Onuma, Yoshinobu, Windecker, Stephan, Tonino, Pim A.L, Roffi, Marco, Lesiak, Maciej, Mahfoud, Felix, Bartunek, Jozef, Hildick-Smith, David, Colombo, Antonio, Stanković, Goran, Iñiguez, Andrés, Schultz, Carl, Kornowski, Ran, Ong, Paul J.L, Alasnag, Mirvat, Rodriguez, Alfredo E, Moschovitis, Aris, Laanmets, Peep, Donahue, Michael, Leonardi, Sergio, Smits, Pieter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome - complications Acute Coronary Syndrome - mortality Acute Coronary Syndrome - therapy Aged Anticoagulation Antiplatelet therapy Biodegradability Bleeding Cardiology Cardiovascular Diseases - mortality Cerebral infarction Consent Coronary Disease Drug delivery Drug Therapy, Combination Drug-Eluting Stents Female Heart Heart attacks Hemorrhage - chemically induced Humans Implants Kaplan-Meier Estimate Male Myocardial Infarction Myocardial Infarction - etiology Patients Percutaneous Coronary Intervention Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - therapeutic use Polymers Rapamycin Research centers Risk Factors Statistical analysis Stents Stroke Stroke - etiology Thromboembolism Thrombosis Thrombosis - prevention & control
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	One month after the implantation of biodegradable-polymer sirolimus-eluting coronary stents, patients at high bleeding risk were randomly assigned to stop dual antiplatelet therapy or to continue it for at least 2 additional months. At 1 year, 1 month of DAPT was noninferior to the longer treatment for ischemic cardiovascular events and was superior for bleeding.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2108749