Higher circulating natural killer cells and lower lactate levels at admission predict spontaneous survival in non-acetaminophen induced acute liver failure

Higher circulating natural killer cells and lower lactate levels at admission predict spontaneous survival in non-acetaminophen induced acute liver failure

Massive cellular necrosis in acute liver failure (ALF) is dominantly immune mediated and innate immune cells are major pathophysiological determinants in liver damage. In fifty ALF and fifteen healthy, immune cells phenotyping by flow-cytometry, DAMPs using ELISA were analysed and correlated with cl...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.) Fla.), 2021-10, Vol.231, p.108829-108829, Article 108829
Hauptverfasser: Agrawal, Tanvi, Maiwall, Rakhi, Rajan, V., Bajpai, Meenu, Jagdish, Rakesh Kumar, Sarin, Shiv Kumar, Trehanpati, Nirupma
Format: Artikel
Sprache:eng
Schlagworte:
ALF
DAMPs
Immune cells
Lactate
NK cells
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Zusammenfassung:Massive cellular necrosis in acute liver failure (ALF) is dominantly immune mediated and innate immune cells are major pathophysiological determinants in liver damage. In fifty ALF and fifteen healthy, immune cells phenotyping by flow-cytometry, DAMPs using ELISA were analysed and correlated with clinical and biochemical parameters. ALF patients (aged 27 ± 9 yr, 56% males, 78% viral aetiology) showed no difference in neutrophils and classical monocytes, but significantly increased intermediate monocytes (CD14+CD16+) (p 
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2021.108829