Are DNA–HLA class II interactions the missing link in SLE?

New evidence has emerged that DNA can bind to cell surface HLA class II molecules. If true, this surprising interaction could lead to T cell and B cell activation by DNA, and surface DNA could also provide a target for cell killing by anti-DNA antibodies in systemic lupus erythematosus.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews. Rheumatology 2021-11, Vol.17 (11), p.647-648
1. Verfasser:	Pisetsky, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152 692/4023/1670/1613 692/420/2780 Anti-DNA antibodies Antibodies Antigens Arthritis Cell activation Cell surface Deoxyribonucleic acid Development and progression DNA DNA-ligand interactions Genetic aspects Health aspects Histocompatibility antigen HLA HLA class II antigens Lupus Lymphocytes Lymphocytes T Medicine Medicine & Public Health News & Views news-and-views Pathogenesis Peptides Physiological aspects Proteins Rheumatology Systemic lupus erythematosus T cell receptors
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Beschreibung
Zusammenfassung:	New evidence has emerged that DNA can bind to cell surface HLA class II molecules. If true, this surprising interaction could lead to T cell and B cell activation by DNA, and surface DNA could also provide a target for cell killing by anti-DNA antibodies in systemic lupus erythematosus.
ISSN:	1759-4790 1759-4804
DOI:	10.1038/s41584-021-00684-1