TIM4+ adipose tissue-resident macrophages: new modulators of adiposity

TIM4+ adipose tissue-resident macrophages: new modulators of adiposity

Adipose tissue macrophages (ATMs) have important roles in the regulation of inflammatory responses and insulin resistance in obesity. A new study reports that a subpopulation of ATMs, TIM4 + resident ATMs, modulate adipocyte size via platelet-derived growth factor-CC production during development an...

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Veröffentlicht in:Nature reviews. Endocrinology 2021-11, Vol.17 (11), p.645-646
Hauptverfasser: Huh, Jin Young, Kim, Jae Bum
Format: Artikel
Sprache:eng
Schlagworte:
631/443/319
692/699/2743/393
Adipocytes
Adipose tissue
Body fat
Endocrinology
Inflammation
Insects
Insulin
Insulin resistance
Lipids
Macrophages
Medicine
Medicine & Public Health
Metabolism
News & Views
news-and-views
Nutritional status
Obesity
Platelet-derived growth factor
Regulation
Roles
Stem cells
Thermogenesis
Tumor necrosis factor-TNF
Vascular endothelial growth factor
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Beschreibung
Zusammenfassung:Adipose tissue macrophages (ATMs) have important roles in the regulation of inflammatory responses and insulin resistance in obesity. A new study reports that a subpopulation of ATMs, TIM4 + resident ATMs, modulate adipocyte size via platelet-derived growth factor-CC production during development and diet-induced adipose tissue expansion.
ISSN:1759-5029
1759-5037
DOI:10.1038/s41574-021-00554-6