Intrathecal implantation surgical considerations in rodents; a review

Intrathecal access in humans is a routine clinical intervention. However, intrathecal access is limited to drug delivery purposes in rodents, and intrathecal implantation is not a common surgical practice. Preclinically, we have successfully adopted different intrathecal implantation surgical method...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of neuroscience methods 2021-11, Vol.363, p.109327-109327, Article 109327
Hauptverfasser: Arman, Azim, Hutchinson, Mark R.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 109327
container_issue
container_start_page 109327
container_title Journal of neuroscience methods
container_volume 363
creator Arman, Azim
Hutchinson, Mark R.
description Intrathecal access in humans is a routine clinical intervention. However, intrathecal access is limited to drug delivery purposes in rodents, and intrathecal implantation is not a common surgical practice. Preclinically, we have successfully adopted different intrathecal implantation surgical methods for different implant materials in rodents. However, employing the appropriate intrathecal implantation method is a challenging process for surgeons, which includes several steps such as preoperative evaluations and postoperative care. The aim of this review is to define and compare the major documented surgical approaches applicable for intrathecal implantation in rodents along with the associated side effects, as well as highlighting the critical preoperative and postoperative considerations. Overall, this review will provide surgeons with the principles of intrathecal implantation approaches applicable for different implant materials. •Intrathecal implantation in rodent is a challenging preclinical surgical practice.•Sustainable preoperative and intraoperative procedures are defined.•Major intrathecal implantation procedures in rodents are presented.•Common side effects of the implantation are presented.
doi_str_mv 10.1016/j.jneumeth.2021.109327
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2563420933</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165027021002624</els_id><sourcerecordid>2563420933</sourcerecordid><originalsourceid>FETCH-LOGICAL-c345t-de114f1c32f8e7c5cd67dbebb317292362fa76aeac975cd173a8e180b0d4422a3</originalsourceid><addsrcrecordid>eNqFkE9LxDAQxYMouK5-BenRS9f8aZMWL8qy6sKCFwVvIU2mbso2XZNU8dubtXr2NPDmvWHeD6FLghcEE37dLToHYw9xu6CYkiTWjIojNCOVoDkX1esxmiVjmWMq8Ck6C6HDGBc15jO0WrvoVdyCVrvM9vudclFFO7gsjP7NHlQ9uGAN-B85ZNZlfjDgYrjJVObhw8LnOTpp1S7Axe-co5f71fPyMd88PayXd5tcs6KMuQFCipZoRtsKhC614cI00DSMCFpTxmmrBFegdC3SkgimKiAVbrApCkoVm6Or6e7eD-8jhCh7GzTs0tcwjEHSkrOCpv4sWflk1X4IwUMr9972yn9JguWBm-zkHzd54CYnbil4OwUhFUnlvAzagtNgrAcdpRnsfye-AZjze04</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2563420933</pqid></control><display><type>article</type><title>Intrathecal implantation surgical considerations in rodents; a review</title><source>Elsevier ScienceDirect Journals</source><creator>Arman, Azim ; Hutchinson, Mark R.</creator><creatorcontrib>Arman, Azim ; Hutchinson, Mark R.</creatorcontrib><description>Intrathecal access in humans is a routine clinical intervention. However, intrathecal access is limited to drug delivery purposes in rodents, and intrathecal implantation is not a common surgical practice. Preclinically, we have successfully adopted different intrathecal implantation surgical methods for different implant materials in rodents. However, employing the appropriate intrathecal implantation method is a challenging process for surgeons, which includes several steps such as preoperative evaluations and postoperative care. The aim of this review is to define and compare the major documented surgical approaches applicable for intrathecal implantation in rodents along with the associated side effects, as well as highlighting the critical preoperative and postoperative considerations. Overall, this review will provide surgeons with the principles of intrathecal implantation approaches applicable for different implant materials. •Intrathecal implantation in rodent is a challenging preclinical surgical practice.•Sustainable preoperative and intraoperative procedures are defined.•Major intrathecal implantation procedures in rodents are presented.•Common side effects of the implantation are presented.</description><identifier>ISSN: 0165-0270</identifier><identifier>EISSN: 1872-678X</identifier><identifier>DOI: 10.1016/j.jneumeth.2021.109327</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>3Rs ; Implantation ; Intrathecal space ; Rodents</subject><ispartof>Journal of neuroscience methods, 2021-11, Vol.363, p.109327-109327, Article 109327</ispartof><rights>2021 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-de114f1c32f8e7c5cd67dbebb317292362fa76aeac975cd173a8e180b0d4422a3</citedby><cites>FETCH-LOGICAL-c345t-de114f1c32f8e7c5cd67dbebb317292362fa76aeac975cd173a8e180b0d4422a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165027021002624$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Arman, Azim</creatorcontrib><creatorcontrib>Hutchinson, Mark R.</creatorcontrib><title>Intrathecal implantation surgical considerations in rodents; a review</title><title>Journal of neuroscience methods</title><description>Intrathecal access in humans is a routine clinical intervention. However, intrathecal access is limited to drug delivery purposes in rodents, and intrathecal implantation is not a common surgical practice. Preclinically, we have successfully adopted different intrathecal implantation surgical methods for different implant materials in rodents. However, employing the appropriate intrathecal implantation method is a challenging process for surgeons, which includes several steps such as preoperative evaluations and postoperative care. The aim of this review is to define and compare the major documented surgical approaches applicable for intrathecal implantation in rodents along with the associated side effects, as well as highlighting the critical preoperative and postoperative considerations. Overall, this review will provide surgeons with the principles of intrathecal implantation approaches applicable for different implant materials. •Intrathecal implantation in rodent is a challenging preclinical surgical practice.•Sustainable preoperative and intraoperative procedures are defined.•Major intrathecal implantation procedures in rodents are presented.•Common side effects of the implantation are presented.</description><subject>3Rs</subject><subject>Implantation</subject><subject>Intrathecal space</subject><subject>Rodents</subject><issn>0165-0270</issn><issn>1872-678X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkE9LxDAQxYMouK5-BenRS9f8aZMWL8qy6sKCFwVvIU2mbso2XZNU8dubtXr2NPDmvWHeD6FLghcEE37dLToHYw9xu6CYkiTWjIojNCOVoDkX1esxmiVjmWMq8Ck6C6HDGBc15jO0WrvoVdyCVrvM9vudclFFO7gsjP7NHlQ9uGAN-B85ZNZlfjDgYrjJVObhw8LnOTpp1S7Axe-co5f71fPyMd88PayXd5tcs6KMuQFCipZoRtsKhC614cI00DSMCFpTxmmrBFegdC3SkgimKiAVbrApCkoVm6Or6e7eD-8jhCh7GzTs0tcwjEHSkrOCpv4sWflk1X4IwUMr9972yn9JguWBm-zkHzd54CYnbil4OwUhFUnlvAzagtNgrAcdpRnsfye-AZjze04</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Arman, Azim</creator><creator>Hutchinson, Mark R.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20211101</creationdate><title>Intrathecal implantation surgical considerations in rodents; a review</title><author>Arman, Azim ; Hutchinson, Mark R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-de114f1c32f8e7c5cd67dbebb317292362fa76aeac975cd173a8e180b0d4422a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>3Rs</topic><topic>Implantation</topic><topic>Intrathecal space</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arman, Azim</creatorcontrib><creatorcontrib>Hutchinson, Mark R.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arman, Azim</au><au>Hutchinson, Mark R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrathecal implantation surgical considerations in rodents; a review</atitle><jtitle>Journal of neuroscience methods</jtitle><date>2021-11-01</date><risdate>2021</risdate><volume>363</volume><spage>109327</spage><epage>109327</epage><pages>109327-109327</pages><artnum>109327</artnum><issn>0165-0270</issn><eissn>1872-678X</eissn><abstract>Intrathecal access in humans is a routine clinical intervention. However, intrathecal access is limited to drug delivery purposes in rodents, and intrathecal implantation is not a common surgical practice. Preclinically, we have successfully adopted different intrathecal implantation surgical methods for different implant materials in rodents. However, employing the appropriate intrathecal implantation method is a challenging process for surgeons, which includes several steps such as preoperative evaluations and postoperative care. The aim of this review is to define and compare the major documented surgical approaches applicable for intrathecal implantation in rodents along with the associated side effects, as well as highlighting the critical preoperative and postoperative considerations. Overall, this review will provide surgeons with the principles of intrathecal implantation approaches applicable for different implant materials. •Intrathecal implantation in rodent is a challenging preclinical surgical practice.•Sustainable preoperative and intraoperative procedures are defined.•Major intrathecal implantation procedures in rodents are presented.•Common side effects of the implantation are presented.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.jneumeth.2021.109327</doi><tpages>1</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0165-0270
ispartof Journal of neuroscience methods, 2021-11, Vol.363, p.109327-109327, Article 109327
issn 0165-0270
1872-678X
language eng
recordid cdi_proquest_miscellaneous_2563420933
source Elsevier ScienceDirect Journals
subjects 3Rs
Implantation
Intrathecal space
Rodents
title Intrathecal implantation surgical considerations in rodents; a review
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T23%3A21%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intrathecal%20implantation%20surgical%20considerations%20in%20rodents;%20a%20review&rft.jtitle=Journal%20of%20neuroscience%20methods&rft.au=Arman,%20Azim&rft.date=2021-11-01&rft.volume=363&rft.spage=109327&rft.epage=109327&rft.pages=109327-109327&rft.artnum=109327&rft.issn=0165-0270&rft.eissn=1872-678X&rft_id=info:doi/10.1016/j.jneumeth.2021.109327&rft_dat=%3Cproquest_cross%3E2563420933%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2563420933&rft_id=info:pmid/&rft_els_id=S0165027021002624&rfr_iscdi=true