Liver and Spleen Stiffness Surveillance Through Elastography During and After Direct‐Acting Antiviral Therapy in Patients With Chronic Hepatitis C

Objectives Direct‐acting antiviral agents achieve a high cure rate, resulting in early hepatic necroinflammatory resolution and sustained fibrosis regression. This study aimed to obtain longitudinal, concurrent within‐subject measurements of liver stiffness (LS) and spleen stiffness (SS) and their correlates over time. Methods Participants with hepatitis C (n = 592) receiving direct‐acting antiviral‐based therapy were monitored through point shear‐wave elastography from the treatment baseline (TW0) across follow‐up visits in terms of LS and SS. Results Generalized linear mixed modeling indicated that all LS values (2301 visits) were negatively correlated with the follow‐up times (all P