Meibomian gland atrophy with duration of Sjogren’s syndrome in adult females

Background To investigate the correlation between the duration of Sjögren syndrome (SS) and ocular surface parameters in patients with SS-related dry eye. Methods We analyzed 108 eyes of 108 female patients with primary SS-related dry eye. All patients underwent rheumatoid serologic tests and ocular surface assessments. The ocular surface assessment included the Standard Patient Evaluation of Eye Dryness (SPEED) score, meibomian gland (MG) atrophy, lipid layer thickness (LLT), partial and total blinking, partial blinking rate, Schirmer’s I test, non-invasive tear break-up time, and ocular surface staining score. Correlations between the duration of SS and ocular surface assessments were calculated. Results The average age and SS duration of the participants were 56.7 ± 10.2 (range 21–78) years and 54.15 ± 41.10 (range 1–134) months, respectively. There was a strong positive correlation between SS duration and MG atrophy ( r = 0.766, p