Chronic exposure to low concentrations of chlorpyrifos affects normal cyclicity and histology of the uterus in female rats

Chlorpyrifos (CPF), the most used insecticide in Argentina, can act as an endocrine disruptor at low doses. We previously demonstrated that chronic exposure to CPF induces hormonal imbalance in vivo. The aim of this work was to study the effects of low concentrations of CPF (0.01 and 1 mg/kg/day) on...

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Veröffentlicht in:	Food and chemical toxicology 2021-10, Vol.156, p.112515-112515, Article 112515
Hauptverfasser:	Ramos Nieto, María Rosa, Lasagna, Marianela, Cao, Gabriel, Álvarez, Gloria, Santamaria, Clarisa, Rodriguez Girault, María Eugenia, Bourguignon, Nadia, Di Giorgio, Noelia, Ventura, Clara, Mardirosian, Mariana, Rodriguez, Horacio, Lux-Llantos, Victoria, Cocca, Claudia, Núñez, Mariel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chlorpyrifos Chlorpyrifos - administration & dosage Chlorpyrifos - toxicity Dose-Response Relationship, Drug Drug Administration Schedule Endocrine disruptor Estrous cycle Estrous Cycle - drug effects Female Insecticides - administration & dosage Insecticides - toxicity Ovary - drug effects Random Allocation Rats Rats, Sprague-Dawley Steroidogenesis Uterine endometrium Uterus - drug effects Vagina - drug effects
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