Spatio-temporal distribution of pharmaceutically active compounds in the River Cauvery and its tributaries, South India

Pharmaceutically active compounds (PhACs) present in the environment are a great threat to human well-being and the ecosystem. Eventhough recognized as the pharmacy of the world”, studies addressing the distribution of PhACs in the Indian environment are scarce. Hence, in the current study, selected PhACs, heavy metals (HMs), and physicochemical parameters (PCPs) were measured from the surface waters of the River Cauvery during the pre- and post-monsoon. PhACs such as caffeine, carbamazepine, and diclofenac were detected in most samples, whereas topiramate, ibuprofen, and verapamil were found only in few stations. In contrast, the distribution of ciprofloxacin, atenolol, and isoprenaline was strongly influenced by the seasonal pattern (p < 0.05). PhACs such as loperamide, glafenine, erythromycin, and gemfibrozil were not detected during the study. Distribution of PhACs based on average concentration (ng/L) are, CBZ (205.62) > CAF (114.09) > DCF (28.51) > CIP (25.23) > ATL (18.86) > IPL (13.91) > PPL (11.26) > TCS (10.39) > IBF (7.34) > TPT (3.09) > VPL (1.16). Bivariate and multivariate statistical analyses have revealed a positive correlation expressed by the majority of the PhACs with PCPs (COD, TOC), nutrients (TN, TP), and HMs (Pb, Mn, Ni) in the range from 0.540** to 0.961**(p < 0.01). Whereas, DO revealed negative correlation with most of the parameters in the range from −0.559** to −0.831** (p < 0.01). A high average concentration of PhACs was recorded in the upstream (52.08 ng/L) and wastewater discharge points (55.60 ng/L). Further, the environmental risk assessment study has identified the higher risk exhibited by TCS (RQ: 3.29) and CAF (RQ: 38.82) on algae and Daphnia respectively. The study portrays the distribution of emerging contaminants in the River Cauvery and its tributaries and also delivers preliminary data about the distribution of isoprenaline, topiramate, verapamil, and perindopril in the Indian freshwater system. [Display omitted] •PhACs are emerging contaminants that can affect all lives due to their toxic effects.•Concentrations of most of the pollutants were higher during the post-monsoon.•Cd, Hg, Cu, Ni and Zn expressed correlation with various selected PhACs.•CAF and TCS pose a risk to aquatic lives at various trophic level.•IPL, PPL, and TPT are quantified for the first time from the Indian rivers.