Homocysteine (HCY) levels in patients with atrial fibrillation (AF): A meta‐analysis

Purpose Atrial fibrillation (AF) is one of the most common persistent arrhythmia, and its complications include cerebral embolism, arterial embolism and heart failure. Some studies have found that elevated Homocysteine (HCY) levels is a new risk factor for AF. Currently, there is no meta‐analysis to...

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Veröffentlicht in:International journal of clinical practice (Esher) 2021-12, Vol.75 (12), p.e14738-n/a
Hauptverfasser: Dong, Xin‐Jiang, Wang, Bei‐Bei, Hou, Fei‐Fei, Chen, Kai‐Peng, Zhou, Hui‐Dong, Guo, Jing‐Wei, Sun, Xun, Liu, Xiao‐Li, Chen, Li‐Juan
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Sprache:eng
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Zusammenfassung:Purpose Atrial fibrillation (AF) is one of the most common persistent arrhythmia, and its complications include cerebral embolism, arterial embolism and heart failure. Some studies have found that elevated Homocysteine (HCY) levels is a new risk factor for AF. Currently, there is no meta‐analysis to explore whether the HCY levels is related to AF. Therefore, a meta‐analysis was conducted to evaluate the relationship between the HCY levels and AF, in order to draw the attention of clinicians to the HCY levels. Methods A meta‐analysis was performed in the study to evaluated the association between the HCY levels and AF. In order to identify eligible original articles, The EMBASE, PubMed, and web of science were systematically searched until November 2020. All data were analyzed with Review Manager 5.3. The meta‐analysis results were evaluated depending on standardized mean differences (SMD) with 95% confidence intervals (CI). Moreover, the subgroup analysis and sensitivity analysis were also analyzed. Results The HCY levels was significantly associated with AF (WMD = 0.81, 95% CI: 0.58 to 1.03; P < .00001). In the analysis, there was a medium degree of heterogeneity (I2 = 73%). Subgroup analysis showed that female < 60, BMI≥25, BMI
ISSN:1368-5031
1742-1241
DOI:10.1111/ijcp.14738