Angiogenic potential of mesenchymal stem cells derived from patients with diabetes seeded on decellularized micro fragments

Mesenchymal stem cells (MSCs) are a potential source of angiogenic factors which may promote wound healing in poorly vascularized diabetic foot ulcers. We demonstrate that MSCs of patients with diabetic foot ulcers seeded on decellularized micro-fragments transcribe and secrete angiogenic factors in amounts comparable to MSCs derived from healthy individuals. •MSCs from Diabetic Patients Have Similar Angiogenic Potential as MSCs from Healthy Donors Once seeded on Decellularized Micro Fragments.•The Resulting Vascular Inducing Device (VID) Transcribes and Secretes A Whole Repertoire of Angiogenic Factors.•A Novel Approach for Induce Angiogenesis, Using Only 10 ML of Bone Marrow, Without the Need for Expansion or Enrichment of MSCs.