Triggering receptor expressed on myeloid cells‐2 stimulates osteoclast differentiation and bone loss in periodontitis

Objective To investigate the expression of triggering receptor expressed on myeloid cells 2 (TREM‐2) in the healthy and diseased tissue, including gingivitis or periodontitis, and then to assess whether it has an impact on the development of periodontitis. Methods and materials The gingival tissues...

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Veröffentlicht in:Oral diseases 2022-09, Vol.28 (6), p.1652-1661
Hauptverfasser: Pei, Qing‐guo, Wang, Hai‐cheng, Li, Lin, Wang, Zuo‐lin
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Sprache:eng
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Zusammenfassung:Objective To investigate the expression of triggering receptor expressed on myeloid cells 2 (TREM‐2) in the healthy and diseased tissue, including gingivitis or periodontitis, and then to assess whether it has an impact on the development of periodontitis. Methods and materials The gingival tissues from healthy controls, gingivitis, and periodontitis underwent hematoxylin–eosin and immunohistochemical staining, and the association of TREM‐2 expression or TREM‐2+ cell counts with clinical parameters was assessed. An anti‐TREM‐2 antibody was used to block the osteoclastogenesis in vitro and during the experimental periodontitis by injection into the gingiva. The relative gene expression of TREM‐2 in different gingival tissues was analyzed by quantitative PCR. Results In the gingival tissues of periodontitis, TREM‐2 expression and TREM‐2+ cell counts were significantly higher than those of gingivitis and healthy controls (p
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.14004