Triggering receptor expressed on myeloid cells‐2 stimulates osteoclast differentiation and bone loss in periodontitis
Objective To investigate the expression of triggering receptor expressed on myeloid cells 2 (TREM‐2) in the healthy and diseased tissue, including gingivitis or periodontitis, and then to assess whether it has an impact on the development of periodontitis. Methods and materials The gingival tissues...
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Veröffentlicht in: | Oral diseases 2022-09, Vol.28 (6), p.1652-1661 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Objective
To investigate the expression of triggering receptor expressed on myeloid cells 2 (TREM‐2) in the healthy and diseased tissue, including gingivitis or periodontitis, and then to assess whether it has an impact on the development of periodontitis.
Methods and materials
The gingival tissues from healthy controls, gingivitis, and periodontitis underwent hematoxylin–eosin and immunohistochemical staining, and the association of TREM‐2 expression or TREM‐2+ cell counts with clinical parameters was assessed. An anti‐TREM‐2 antibody was used to block the osteoclastogenesis in vitro and during the experimental periodontitis by injection into the gingiva. The relative gene expression of TREM‐2 in different gingival tissues was analyzed by quantitative PCR.
Results
In the gingival tissues of periodontitis, TREM‐2 expression and TREM‐2+ cell counts were significantly higher than those of gingivitis and healthy controls (p |
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ISSN: | 1354-523X 1601-0825 |
DOI: | 10.1111/odi.14004 |