Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters

α-ketoglutarate (KG), also referred to as 2-oxoglutarate, is a key intermediate of cellular metabolism with pleiotropic functions. Cell-permeable esterified analogs are widely used to study how KG fuels bioenergetic and amino acid metabolism and DNA, RNA, and protein hydroxylation reactions, as cell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2021-08, Vol.12 (1), p.4905-4905, Article 4905
Hauptverfasser:	Parker, Seth J., Encarnación-Rosado, Joel, Hollinshead, Kate E. R., Hollinshead, David M., Ash, Leonard J., Rossi, Juan A. K., Lin, Elaine Y., Sohn, Albert S. W., Philips, Mark R., Jones, Drew R., Kimmelman, Alec C.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 38/44 631/1647/296 631/45/320 631/92/1643 631/92/2783 82/58 96/10 Acidification Amino acids Analogs Aqueous solutions Cell lines Cell membranes Cytosol Deoxyribonucleic acid DNA Esterification Esters Glycolysis Humanities and Social Sciences Hydrolysis Hydroxylation Imports Ketoesters Ketoglutaric acid Metabolism Mitochondria multidisciplinary Multidisciplinary Sciences Nuclear fuels Nuclear reactions Protein turnover Protonation Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!