Changes in bone mineral density in Down syndrome individuals: a systematic review and meta-analysis

Changes in bone mineral density in Down syndrome individuals: a systematic review and meta-analysis

Data evaluating changes in bone mineral density (BMD) in Down syndrome (DS) individuals remains controversial. Therefore, we conducted a systematic review and meta-analysis to better understand associations between BMD and DS. A systematic literature search of PubMed, EMBASE, Web of Science, and the...

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Veröffentlicht in:Osteoporosis international 2022, Vol.33 (1), p.27-37
Hauptverfasser: Zhang, Y., Tian, Z., Ye, S., Mu, Q., Wang, X., Ren, S., Hou, X., Yu, W., Guo, J.
Format: Artikel
Sprache:eng
Schlagworte:
Absorptiometry, Photon
Bone Density
Bone mineral density
Down syndrome
Down Syndrome - complications
Down's syndrome
Endocrinology
Femur
Femur Neck
Humans
Lumbar Vertebrae
Medicine
Medicine & Public Health
Meta-analysis
Orthopedics
Osteoporosis
Review
Rheumatology
Spine (lumbar)
Systematic review
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Zusammenfassung:Data evaluating changes in bone mineral density (BMD) in Down syndrome (DS) individuals remains controversial. Therefore, we conducted a systematic review and meta-analysis to better understand associations between BMD and DS. A systematic literature search of PubMed, EMBASE, Web of Science, and the Cochrane Library up until 1st January 2021 was conducted. We used the keywords “bone mineral density” and “Down Syndrome.” Fifteen studies were included. Overall, our results showed a significant decrease in BMD of total body (TB BMD) [MD =  − 0.18; 95% CI (− 0.23 and − 0.12), P  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-021-06070-7