Expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death

The diagnosis of drug-induced anaphylactic death is an important component of forensic medicine. The purpose of this study was to explore the expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death and its value for forensic medicine. The expression of FcεRIα an...

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Veröffentlicht in:Forensic science, medicine, and pathology medicine, and pathology, 2021-12, Vol.17 (4), p.547-552
Hauptverfasser: Feng, Chunmei, Zhang, Chaoxu, Wang, Pengfei, Wang, Xiaolong, You, Jiabin, Zhang, Guohua, Yu, Hao
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Sprache:eng
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Zusammenfassung:The diagnosis of drug-induced anaphylactic death is an important component of forensic medicine. The purpose of this study was to explore the expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death and its value for forensic medicine. The expression of FcεRIα and tryptase in lung tissues of the drug-induced anaphylactic death group (n = 30) and control group (who died due to sudden cardiac death, falling from a height, or traffic accidents, n = 30) was detected by immunohistochemistry and immunofluorescence staining. The difference in FcεRIα and tryptase expression in the lung tissue between the drug-induced anaphylactic death group and the control group was statistically significant (p 
ISSN:1547-769X
1556-2891
DOI:10.1007/s12024-021-00405-w