Synergic effects of ultrasound and laser therapies on mesentery for management of obesity and diabetes in rats
Nowadays, the mesentery as a new organ was discovered. Mesenteric events may play an important role in the pathophysiology of several diseases. The aim of our study was investigate the synergic effects of ultrasound (US) and laser therapies on mesentery in obese‐hyperglycemic rats. The 25 male Wista...
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Veröffentlicht in: | Journal of biophotonics 2021-11, Vol.14 (11), p.e202100109-n/a |
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Zusammenfassung: | Nowadays, the mesentery as a new organ was discovered. Mesenteric events may play an important role in the pathophysiology of several diseases. The aim of our study was investigate the synergic effects of ultrasound (US) and laser therapies on mesentery in obese‐hyperglycemic rats. The 25 male Wistar rats were randomized into five groups. Obese nondiabetic (OND) group: obese rats without diabetes and no treatment conditions; SHAM group: obese‐hyperglycemic rats treated with placebo; US group: obese‐hyperglycemic rats treated with US; LASER group: obese‐hyperglycemic rats treated with laser and; US+LASER group: obese‐hyperglycemic rats treated with US plus laser. An animal model of type 2 diabetes based on a hyperlipidemic diet combined with a low dose of streptozotocin was used in this study. Body mass and biochemical measurements were performed. GOT and GPT level showed a significant reduction in the treated groups than SHAM. The total cholesterol, triglycerides and very low‐density lipoprotein (VLDL) levels showed significantly lower values for the US+LASER group. There was also reduced risk of cardiovascular diseases evidenced by Castelli index in the treated groups than SHAM. This study showed that the US and laser treatment on mesentery resulted to an improvement in biochemical measurements of the obese‐hyperglycemic rats, especially the total cholesterol, triglycerides and VLDL levels.
Nowadays, the mesentery as a new organ was discovered. Mesenteric events may play an important role in the pathophysiology not only in abdominal diseases, but also in nonabdominal diseases (eg, obesity and diabetes) due to biologic activity of mesenteric lymph and, anatomical, biochemical and metabolic characteristics of mesenteric adipose tissue. An animal study was conducted to investigate the synergic effects of ultrasound and laser therapies on mesentery in obese‐hyperglycemic rats. The association of ultrasound and laser treatment on mesentery resulted to an improvement in biochemical measurements of the obese‐hyperglycemic rats, especially the total cholesterol, triglycerides and very low‐density lipoprotein (VLDL) levels. |
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ISSN: | 1864-063X 1864-0648 |
DOI: | 10.1002/jbio.202100109 |