Increased renal function decline in fast metabolizers using extended-release tacrolimus after kidney transplantation

Fast metabolism of immediate-release tacrolimus (IR-Tac) is associated with decreased kidney function after renal transplantation (RTx) compared to slow metabolizers. We hypothesized, by analogy, that fast metabolism of extended-release tacrolimus (ER-Tac) is associated with worse renal function. We...

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Veröffentlicht in:	Scientific reports 2021-08, Vol.11 (1), p.15606-13, Article 15606
Hauptverfasser:	Thölking, Gerold, Filensky, Brigitte, Jehn, Ulrich, Schütte-Nütgen, Katharina, Koch, Raphael, Kurschat, Christine, Pavenstädt, Hermann, Suwelack, Barbara, Reuter, Stefan, Kuypers, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308 692/4022 Adult Aged Corticosteroids Delayed-Action Preparations Epidermal growth factor receptors Female Glomerular Filtration Rate Graft rejection Graft Rejection - metabolism Graft Rejection - prevention & control Graft Survival - drug effects Humanities and Social Sciences Humans Immunosuppression Immunosuppressive agents Immunosuppressive Agents - administration & dosage Kidney - drug effects Kidney - metabolism Kidney - physiopathology Kidney transplantation Kidney Transplantation - adverse effects Kidney transplants Male Metabolism Middle Aged multidisciplinary Multidisciplinary Sciences Mycophenolic acid Patients Renal function Retrospective Studies Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Survival Tacrolimus Tacrolimus - administration & dosage Tacrolimus - pharmacokinetics Transplants & implants
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Zusammenfassung:	Fast metabolism of immediate-release tacrolimus (IR-Tac) is associated with decreased kidney function after renal transplantation (RTx) compared to slow metabolizers. We hypothesized, by analogy, that fast metabolism of extended-release tacrolimus (ER-Tac) is associated with worse renal function. We analyzed data from patients who underwent RTx at three different transplant centers between 2007 and 2016 and received an initial immunosuppressive regimen with ER-Tac, mycophenolate, and a corticosteroid. Three months after RTx, a Tac concentration to dose ratio (C/D ratio)
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-95201-5