Impact of Tumor Burden Score on Conditional Survival after Curative-Intent Resection for Hepatocellular Carcinoma: A Multi-Institutional Analysis
Background The impact of tumor burden score (TBS) on conditional survival (CS) among patients undergoing curative-intent resection of hepatocellular carcinoma (HCC) has not been examined to date. Methods Patients who underwent liver resection of HCC between 2000 and 2017 were identified from a multi...
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| Veröffentlicht in: | World journal of surgery 2021-11, Vol.45 (11), p.3438-3448 |
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| creator | Elfadaly, Ahmed N. Tsilimigras, Diamantis I. Hyer, J. Madison Paro, Alessandro Bagante, Fabio Ratti, Francesca Marques, Hugo P. Soubrane, Olivier Lam, Vincent Poultsides, George A. Popescu, Irinel Alexandrescu, Sorin Martel, Guillaume Workneh, Aklile Guglielmi, Alfredo Hugh, Tom Aldrighetti, Luca Endo, Itaru Pawlik, Timothy M. |
| description | Background
The impact of tumor burden score (TBS) on conditional survival (CS) among patients undergoing curative-intent resection of hepatocellular carcinoma (HCC) has not been examined to date.
Methods
Patients who underwent liver resection of HCC between 2000 and 2017 were identified from a multi-institutional database. The impact of TBS and other clinicopathologic factors on 3-year conditional survival (CS
3
) was examined.
Results
Among 1,040 patients, 263 (25.3%) patients had low TBS, 668 (64.2%) had medium TBS and 109 (10.5%) had high TBS. TBS was strongly associated with OS; 5-year OS was 39.0% among patients with high TBS compared with 61.1% and 79.4% among patients with medium and low TBS, respectively (
p
|
| doi_str_mv | 10.1007/s00268-021-06265-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2557548300</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2557548300</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4984-12cec242a0a6eba6ca98c5dc75031380e3d25121ea2476e33aa897f3489dbc4d3</originalsourceid><addsrcrecordid>eNqNkc1u1DAYRS0EokPhBVggS2y6CfgvTtLddETpVEVITBFLy-N8Qa6SePDPoHkM3hiHDEXqAnVje3HO1bUuQq8peUcJqd4HQpisC8JoQSSTZcGfoAUVnBWMM_4ULQiXIr8pP0EvQrgjhFaSyOfohAsuaC3EAv1aDzttInYdvk2D8_gi-RZGvDHOA3YjXrmxtdG6Ufd4k_ze7vNDdxE8XiWvo91DsR4jjBF_gQBmQnGXg65gp6Mz0Pep1xnW3tjRDfocL_Gn1EebtRBtTMfwZT4OwYaX6Fmn-wCvjvcp-nr54XZ1Vdx8_rheLW8KI5paFJQZMEwwTbSErZZGN7UpW1OVJH-4JsBbVlJGQTNRSeBc67qpOi7qpt0a0fJTdDbn7rz7kSBENdgw1dUjuBQUK8uqFDUnJKNvH6B3Lvncd6IqWfGmYjJTbKaMdyF46NTO20H7g6JETYOpeTCVB1N_BlM8S2-O0Wk7QHuv_F0oA-cz8NP2cHhEpPp2vbm4JJSVk8xnOWRv_A7-X_H_dPoNLW2zMg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2576739726</pqid></control><display><type>article</type><title>Impact of Tumor Burden Score on Conditional Survival after Curative-Intent Resection for Hepatocellular Carcinoma: A Multi-Institutional Analysis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SpringerLink Journals</source><creator>Elfadaly, Ahmed N. ; Tsilimigras, Diamantis I. ; Hyer, J. Madison ; Paro, Alessandro ; Bagante, Fabio ; Ratti, Francesca ; Marques, Hugo P. ; Soubrane, Olivier ; Lam, Vincent ; Poultsides, George A. ; Popescu, Irinel ; Alexandrescu, Sorin ; Martel, Guillaume ; Workneh, Aklile ; Guglielmi, Alfredo ; Hugh, Tom ; Aldrighetti, Luca ; Endo, Itaru ; Pawlik, Timothy M.</creator><creatorcontrib>Elfadaly, Ahmed N. ; Tsilimigras, Diamantis I. ; Hyer, J. Madison ; Paro, Alessandro ; Bagante, Fabio ; Ratti, Francesca ; Marques, Hugo P. ; Soubrane, Olivier ; Lam, Vincent ; Poultsides, George A. ; Popescu, Irinel ; Alexandrescu, Sorin ; Martel, Guillaume ; Workneh, Aklile ; Guglielmi, Alfredo ; Hugh, Tom ; Aldrighetti, Luca ; Endo, Itaru ; Pawlik, Timothy M.</creatorcontrib><description>Background
The impact of tumor burden score (TBS) on conditional survival (CS) among patients undergoing curative-intent resection of hepatocellular carcinoma (HCC) has not been examined to date.
Methods
Patients who underwent liver resection of HCC between 2000 and 2017 were identified from a multi-institutional database. The impact of TBS and other clinicopathologic factors on 3-year conditional survival (CS
3
) was examined.
Results
Among 1,040 patients, 263 (25.3%) patients had low TBS, 668 (64.2%) had medium TBS and 109 (10.5%) had high TBS. TBS was strongly associated with OS; 5-year OS was 39.0% among patients with high TBS compared with 61.1% and 79.4% among patients with medium and low TBS, respectively (
p
< 0.001). While actuarial survival decreased as time elapsed from resection, CS increased over time irrespective of TBS. The largest differences between 3-year actuarial survival and CS
3
were noted among patients with high TBS (5-years postoperatively; CS
3
: 78.7% vs. 3-year actuarial survival: 30.7%). The effect of adverse clinicopathologic factors including high TBS, poor/undifferentiated tumor grade, microvascular invasion, liver capsule involvement, and positive margins on prognosis decreased over time.
Conclusions
CS rates among patients who underwent resection for HCC increased as patients survived additional years, irrespective of TBS. CS estimates can be used to provide important dynamic information relative to the changing survival probability after resection of HCC.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-021-06265-3</identifier><identifier>PMID: 34341844</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdominal Surgery ; Carcinoma, Hepatocellular - surgery ; Cardiac Surgery ; Conditioned stimulus ; General Surgery ; Hepatectomy ; Hepatocellular carcinoma ; Humans ; Impact analysis ; Liver ; Liver cancer ; Liver Neoplasms - surgery ; Medical prognosis ; Medicine ; Medicine & Public Health ; Microvasculature ; Original Scientific Report ; Prognosis ; Retrospective Studies ; Surgery ; Survival ; Thoracic Surgery ; Tumor Burden ; Tumors ; Vascular Surgery</subject><ispartof>World journal of surgery, 2021-11, Vol.45 (11), p.3438-3448</ispartof><rights>Société Internationale de Chirurgie 2021</rights><rights>2021 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>2021. Société Internationale de Chirurgie.</rights><rights>Société Internationale de Chirurgie 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4984-12cec242a0a6eba6ca98c5dc75031380e3d25121ea2476e33aa897f3489dbc4d3</citedby><cites>FETCH-LOGICAL-c4984-12cec242a0a6eba6ca98c5dc75031380e3d25121ea2476e33aa897f3489dbc4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-021-06265-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-021-06265-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,41464,42533,45550,45551,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34341844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elfadaly, Ahmed N.</creatorcontrib><creatorcontrib>Tsilimigras, Diamantis I.</creatorcontrib><creatorcontrib>Hyer, J. Madison</creatorcontrib><creatorcontrib>Paro, Alessandro</creatorcontrib><creatorcontrib>Bagante, Fabio</creatorcontrib><creatorcontrib>Ratti, Francesca</creatorcontrib><creatorcontrib>Marques, Hugo P.</creatorcontrib><creatorcontrib>Soubrane, Olivier</creatorcontrib><creatorcontrib>Lam, Vincent</creatorcontrib><creatorcontrib>Poultsides, George A.</creatorcontrib><creatorcontrib>Popescu, Irinel</creatorcontrib><creatorcontrib>Alexandrescu, Sorin</creatorcontrib><creatorcontrib>Martel, Guillaume</creatorcontrib><creatorcontrib>Workneh, Aklile</creatorcontrib><creatorcontrib>Guglielmi, Alfredo</creatorcontrib><creatorcontrib>Hugh, Tom</creatorcontrib><creatorcontrib>Aldrighetti, Luca</creatorcontrib><creatorcontrib>Endo, Itaru</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><title>Impact of Tumor Burden Score on Conditional Survival after Curative-Intent Resection for Hepatocellular Carcinoma: A Multi-Institutional Analysis</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
The impact of tumor burden score (TBS) on conditional survival (CS) among patients undergoing curative-intent resection of hepatocellular carcinoma (HCC) has not been examined to date.
Methods
Patients who underwent liver resection of HCC between 2000 and 2017 were identified from a multi-institutional database. The impact of TBS and other clinicopathologic factors on 3-year conditional survival (CS
3
) was examined.
Results
Among 1,040 patients, 263 (25.3%) patients had low TBS, 668 (64.2%) had medium TBS and 109 (10.5%) had high TBS. TBS was strongly associated with OS; 5-year OS was 39.0% among patients with high TBS compared with 61.1% and 79.4% among patients with medium and low TBS, respectively (
p
< 0.001). While actuarial survival decreased as time elapsed from resection, CS increased over time irrespective of TBS. The largest differences between 3-year actuarial survival and CS
3
were noted among patients with high TBS (5-years postoperatively; CS
3
: 78.7% vs. 3-year actuarial survival: 30.7%). The effect of adverse clinicopathologic factors including high TBS, poor/undifferentiated tumor grade, microvascular invasion, liver capsule involvement, and positive margins on prognosis decreased over time.
Conclusions
CS rates among patients who underwent resection for HCC increased as patients survived additional years, irrespective of TBS. CS estimates can be used to provide important dynamic information relative to the changing survival probability after resection of HCC.</description><subject>Abdominal Surgery</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cardiac Surgery</subject><subject>Conditioned stimulus</subject><subject>General Surgery</subject><subject>Hepatectomy</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Impact analysis</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - surgery</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Original Scientific Report</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival</subject><subject>Thoracic Surgery</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1u1DAYRS0EokPhBVggS2y6CfgvTtLddETpVEVITBFLy-N8Qa6SePDPoHkM3hiHDEXqAnVje3HO1bUuQq8peUcJqd4HQpisC8JoQSSTZcGfoAUVnBWMM_4ULQiXIr8pP0EvQrgjhFaSyOfohAsuaC3EAv1aDzttInYdvk2D8_gi-RZGvDHOA3YjXrmxtdG6Ufd4k_ze7vNDdxE8XiWvo91DsR4jjBF_gQBmQnGXg65gp6Mz0Pep1xnW3tjRDfocL_Gn1EebtRBtTMfwZT4OwYaX6Fmn-wCvjvcp-nr54XZ1Vdx8_rheLW8KI5paFJQZMEwwTbSErZZGN7UpW1OVJH-4JsBbVlJGQTNRSeBc67qpOi7qpt0a0fJTdDbn7rz7kSBENdgw1dUjuBQUK8uqFDUnJKNvH6B3Lvncd6IqWfGmYjJTbKaMdyF46NTO20H7g6JETYOpeTCVB1N_BlM8S2-O0Wk7QHuv_F0oA-cz8NP2cHhEpPp2vbm4JJSVk8xnOWRv_A7-X_H_dPoNLW2zMg</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Elfadaly, Ahmed N.</creator><creator>Tsilimigras, Diamantis I.</creator><creator>Hyer, J. Madison</creator><creator>Paro, Alessandro</creator><creator>Bagante, Fabio</creator><creator>Ratti, Francesca</creator><creator>Marques, Hugo P.</creator><creator>Soubrane, Olivier</creator><creator>Lam, Vincent</creator><creator>Poultsides, George A.</creator><creator>Popescu, Irinel</creator><creator>Alexandrescu, Sorin</creator><creator>Martel, Guillaume</creator><creator>Workneh, Aklile</creator><creator>Guglielmi, Alfredo</creator><creator>Hugh, Tom</creator><creator>Aldrighetti, Luca</creator><creator>Endo, Itaru</creator><creator>Pawlik, Timothy M.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Impact of Tumor Burden Score on Conditional Survival after Curative-Intent Resection for Hepatocellular Carcinoma: A Multi-Institutional Analysis</title><author>Elfadaly, Ahmed N. ; Tsilimigras, Diamantis I. ; Hyer, J. Madison ; Paro, Alessandro ; Bagante, Fabio ; Ratti, Francesca ; Marques, Hugo P. ; Soubrane, Olivier ; Lam, Vincent ; Poultsides, George A. ; Popescu, Irinel ; Alexandrescu, Sorin ; Martel, Guillaume ; Workneh, Aklile ; Guglielmi, Alfredo ; Hugh, Tom ; Aldrighetti, Luca ; Endo, Itaru ; Pawlik, Timothy M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4984-12cec242a0a6eba6ca98c5dc75031380e3d25121ea2476e33aa897f3489dbc4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdominal Surgery</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cardiac Surgery</topic><topic>Conditioned stimulus</topic><topic>General Surgery</topic><topic>Hepatectomy</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Impact analysis</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - surgery</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvasculature</topic><topic>Original Scientific Report</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Survival</topic><topic>Thoracic Surgery</topic><topic>Tumor Burden</topic><topic>Tumors</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elfadaly, Ahmed N.</creatorcontrib><creatorcontrib>Tsilimigras, Diamantis I.</creatorcontrib><creatorcontrib>Hyer, J. Madison</creatorcontrib><creatorcontrib>Paro, Alessandro</creatorcontrib><creatorcontrib>Bagante, Fabio</creatorcontrib><creatorcontrib>Ratti, Francesca</creatorcontrib><creatorcontrib>Marques, Hugo P.</creatorcontrib><creatorcontrib>Soubrane, Olivier</creatorcontrib><creatorcontrib>Lam, Vincent</creatorcontrib><creatorcontrib>Poultsides, George A.</creatorcontrib><creatorcontrib>Popescu, Irinel</creatorcontrib><creatorcontrib>Alexandrescu, Sorin</creatorcontrib><creatorcontrib>Martel, Guillaume</creatorcontrib><creatorcontrib>Workneh, Aklile</creatorcontrib><creatorcontrib>Guglielmi, Alfredo</creatorcontrib><creatorcontrib>Hugh, Tom</creatorcontrib><creatorcontrib>Aldrighetti, Luca</creatorcontrib><creatorcontrib>Endo, Itaru</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elfadaly, Ahmed N.</au><au>Tsilimigras, Diamantis I.</au><au>Hyer, J. Madison</au><au>Paro, Alessandro</au><au>Bagante, Fabio</au><au>Ratti, Francesca</au><au>Marques, Hugo P.</au><au>Soubrane, Olivier</au><au>Lam, Vincent</au><au>Poultsides, George A.</au><au>Popescu, Irinel</au><au>Alexandrescu, Sorin</au><au>Martel, Guillaume</au><au>Workneh, Aklile</au><au>Guglielmi, Alfredo</au><au>Hugh, Tom</au><au>Aldrighetti, Luca</au><au>Endo, Itaru</au><au>Pawlik, Timothy M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Tumor Burden Score on Conditional Survival after Curative-Intent Resection for Hepatocellular Carcinoma: A Multi-Institutional Analysis</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2021-11</date><risdate>2021</risdate><volume>45</volume><issue>11</issue><spage>3438</spage><epage>3448</epage><pages>3438-3448</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
The impact of tumor burden score (TBS) on conditional survival (CS) among patients undergoing curative-intent resection of hepatocellular carcinoma (HCC) has not been examined to date.
Methods
Patients who underwent liver resection of HCC between 2000 and 2017 were identified from a multi-institutional database. The impact of TBS and other clinicopathologic factors on 3-year conditional survival (CS
3
) was examined.
Results
Among 1,040 patients, 263 (25.3%) patients had low TBS, 668 (64.2%) had medium TBS and 109 (10.5%) had high TBS. TBS was strongly associated with OS; 5-year OS was 39.0% among patients with high TBS compared with 61.1% and 79.4% among patients with medium and low TBS, respectively (
p
< 0.001). While actuarial survival decreased as time elapsed from resection, CS increased over time irrespective of TBS. The largest differences between 3-year actuarial survival and CS
3
were noted among patients with high TBS (5-years postoperatively; CS
3
: 78.7% vs. 3-year actuarial survival: 30.7%). The effect of adverse clinicopathologic factors including high TBS, poor/undifferentiated tumor grade, microvascular invasion, liver capsule involvement, and positive margins on prognosis decreased over time.
Conclusions
CS rates among patients who underwent resection for HCC increased as patients survived additional years, irrespective of TBS. CS estimates can be used to provide important dynamic information relative to the changing survival probability after resection of HCC.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>34341844</pmid><doi>10.1007/s00268-021-06265-3</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-2313 |
| ispartof | World journal of surgery, 2021-11, Vol.45 (11), p.3438-3448 |
| issn | 0364-2313 1432-2323 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2557548300 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SpringerLink Journals |
| subjects | Abdominal Surgery Carcinoma, Hepatocellular - surgery Cardiac Surgery Conditioned stimulus General Surgery Hepatectomy Hepatocellular carcinoma Humans Impact analysis Liver Liver cancer Liver Neoplasms - surgery Medical prognosis Medicine Medicine & Public Health Microvasculature Original Scientific Report Prognosis Retrospective Studies Surgery Survival Thoracic Surgery Tumor Burden Tumors Vascular Surgery |
| title | Impact of Tumor Burden Score on Conditional Survival after Curative-Intent Resection for Hepatocellular Carcinoma: A Multi-Institutional Analysis |
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