Impact of Tumor Burden Score on Conditional Survival after Curative-Intent Resection for Hepatocellular Carcinoma: A Multi-Institutional Analysis

Impact of Tumor Burden Score on Conditional Survival after Curative-Intent Resection for Hepatocellular Carcinoma: A Multi-Institutional Analysis

Background The impact of tumor burden score (TBS) on conditional survival (CS) among patients undergoing curative-intent resection of hepatocellular carcinoma (HCC) has not been examined to date. Methods Patients who underwent liver resection of HCC between 2000 and 2017 were identified from a multi...

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Veröffentlicht in:World journal of surgery 2021-11, Vol.45 (11), p.3438-3448
Hauptverfasser: Elfadaly, Ahmed N., Tsilimigras, Diamantis I., Hyer, J. Madison, Paro, Alessandro, Bagante, Fabio, Ratti, Francesca, Marques, Hugo P., Soubrane, Olivier, Lam, Vincent, Poultsides, George A., Popescu, Irinel, Alexandrescu, Sorin, Martel, Guillaume, Workneh, Aklile, Guglielmi, Alfredo, Hugh, Tom, Aldrighetti, Luca, Endo, Itaru, Pawlik, Timothy M.
Format: Artikel
Sprache:eng
Schlagworte:
Abdominal Surgery
Carcinoma, Hepatocellular - surgery
Cardiac Surgery
Conditioned stimulus
General Surgery
Hepatectomy
Hepatocellular carcinoma
Humans
Impact analysis
Liver
Liver cancer
Liver Neoplasms - surgery
Medical prognosis
Medicine
Medicine & Public Health
Microvasculature
Original Scientific Report
Prognosis
Retrospective Studies
Surgery
Survival
Thoracic Surgery
Tumor Burden
Tumors
Vascular Surgery
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Zusammenfassung:Background The impact of tumor burden score (TBS) on conditional survival (CS) among patients undergoing curative-intent resection of hepatocellular carcinoma (HCC) has not been examined to date. Methods Patients who underwent liver resection of HCC between 2000 and 2017 were identified from a multi-institutional database. The impact of TBS and other clinicopathologic factors on 3-year conditional survival (CS 3 ) was examined. Results Among 1,040 patients, 263 (25.3%) patients had low TBS, 668 (64.2%) had medium TBS and 109 (10.5%) had high TBS. TBS was strongly associated with OS; 5-year OS was 39.0% among patients with high TBS compared with 61.1% and 79.4% among patients with medium and low TBS, respectively ( p  
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-021-06265-3