Illuminating Plasmodium invasion by lattice-light-sheet microscopy

Illuminating Plasmodium invasion by lattice-light-sheet microscopy

Plasmodium merozoites invade erythrocytes in a stepwise manner through ligand binding, calcium signaling, and membrane deformation. Using a recently developed light-sheet microscope, Geoghegan et al. investigated invasion with unprecedented temporal resolution. Their spectacular footage revealed rol...

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Veröffentlicht in:Trends in parasitology 2021-09, Vol.37 (9), p.777-779
Hauptverfasser: Ganter, Markus, Frischknecht, Friedrich
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container_title Trends in parasitology
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creator Ganter, Markus
Frischknecht, Friedrich
description Plasmodium merozoites invade erythrocytes in a stepwise manner through ligand binding, calcium signaling, and membrane deformation. Using a recently developed light-sheet microscope, Geoghegan et al. investigated invasion with unprecedented temporal resolution. Their spectacular footage revealed roles for host cell cholesterol and pore formation at the parasite–host cell interface.
doi_str_mv 10.1016/j.pt.2021.07.008
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title Illuminating Plasmodium invasion by lattice-light-sheet microscopy
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