Illuminating Plasmodium invasion by lattice-light-sheet microscopy
Plasmodium merozoites invade erythrocytes in a stepwise manner through ligand binding, calcium signaling, and membrane deformation. Using a recently developed light-sheet microscope, Geoghegan et al. investigated invasion with unprecedented temporal resolution. Their spectacular footage revealed rol...
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| Veröffentlicht in: | Trends in parasitology 2021-09, Vol.37 (9), p.777-779 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Plasmodium merozoites invade erythrocytes in a stepwise manner through ligand binding, calcium signaling, and membrane deformation. Using a recently developed light-sheet microscope, Geoghegan et al. investigated invasion with unprecedented temporal resolution. Their spectacular footage revealed roles for host cell cholesterol and pore formation at the parasite–host cell interface. |
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| ISSN: | 1471-4922 1471-5007 |
| DOI: | 10.1016/j.pt.2021.07.008 |