Effect of Telmisartan on Arsenic-Induced (Sub-chronic) Perturbations in Redox Homeostasis, Pro-inflammatory Cascade and Aortic Dysfunction in Wistar Rats

An experimental study was conducted in male Wistar rats to explore the antioxidant potential of telmisartan (an AT 1 receptor blocker) to overcome arsenic (‘As’)-induced perturbations in redox homeostasis pro-inflammatory cytokines, prostaglandin-E 2 levels and aortic dysfunction in Wistar rats. Wis...

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Veröffentlicht in:	Biological trace element research 2022-04, Vol.200 (4), p.1776-1790
Hauptverfasser:	Gowda, B. Rudresh, Prakash, N., Santhosh, C. R., Pavithra, B. H., Rajashekaraiah, Rashmi, Sathyanarayana, M. L., Rao, Suguna, Waghe, Prashantkumar, Kumar, K. R. Anjan, Shivaprasad, G. R., Muralidhar, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Animals Anions Antioxidants Antioxidants - metabolism Aorta Aorta - metabolism Aqueous solutions Arsenic Arsenic - pharmacology Arsenite Attenuation Biochemistry Biomedical and Life Sciences Biotechnology Chronic exposure Connective tissue Connective tissues Coronary vessels CYBB protein Cyclooxygenase-2 Cytokines Drinking water Exposure Gene expression Histopathology Homeostasis IL-1β Inflammation Interleukin 6 Life Sciences Lipid Peroxidation Lipids Male Malondialdehyde Nucleotide sequence Nutrition Oncology Oxidative Stress Oxidoreductions PCR Peroxidation Perturbation Perturbations Polymerase chain reaction Prostaglandin E2 Proteins Rats Rats, Wistar Receptors Reduction Restoration Rodents Sodium Sodium arsenite Superoxide anions Telmisartan - pharmacology Thiobarbituric acid Tumor necrosis factor-α
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Zusammenfassung:	An experimental study was conducted in male Wistar rats to explore the antioxidant potential of telmisartan (an AT 1 receptor blocker) to overcome arsenic (‘As’)-induced perturbations in redox homeostasis pro-inflammatory cytokines, prostaglandin-E 2 levels and aortic dysfunction in Wistar rats. Wistar rats were randomly divided into four groups of six each. Group-I served as untreated control, while group-II received sodium (meta) arsenite (NaAsO 2 ) (10 mg/kg b.wt. p.o ) for a period of 60 days. Experimental rats in group-III received treatment similar to group-II, but in addition received telmisartan (with 1% aqueous solution of Tween 80) @ 10 mg/kg b.wt. ( p.o ) for a similar duration, while rats in group-IV received telmisartan alone. Arsenic exposure resulted in significant ( p
ISSN:	0163-4984 1559-0720
DOI:	10.1007/s12011-021-02804-0