Relationship between Low and High Anti-acetylcholine Receptor Antibody Titers and Clinical Severity in Myasthenia Gravis

Relationship between Low and High Anti-acetylcholine Receptor Antibody Titers and Clinical Severity in Myasthenia Gravis

Objective: To determine the frequency of low and high anti-AChR (acetylcholine receptor) antibody titers and to evaluate their relationship with clinical severity in myasthenia gravis. Study Design: Cross-sectional, observational study. Place and Duration of Study: Department of Neurology, King Edwa...

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Veröffentlicht in:Journal of the College of Physicians and Surgeons--Pakistan 2021-08, Vol.31 (8), p.965-968
Hauptverfasser: Ullah, Ubaid, Iftikhar, Sadaf, Javed, Muhammad Athar
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine
Anti-antibodies
Development and progression
Diagnosis
Health aspects
Myasthenia gravis
Receptors
Risk factors
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Zusammenfassung:Objective: To determine the frequency of low and high anti-AChR (acetylcholine receptor) antibody titers and to evaluate their relationship with clinical severity in myasthenia gravis. Study Design: Cross-sectional, observational study. Place and Duration of Study: Department of Neurology, King Edward Medical University/Mayo Hospital, Lahore from April 2017 to March 2018. Methodology: Fifty-six seropositive patients, aged between 18-75 years, were included. A blood sample was obtained from each patient to assess for the anti-AChR antibody titers by enzyme-linked immunosorbent assay (ELISA) technique and classified as low (0.4-
ISSN:1022-386X
1681-7168
DOI:10.29271/jcpsp.2021.08.965