T cell exhaustion—a memory locked behind scars

T cell exhaustion—a memory locked behind scars

Following clearance of chronic infections, virus-specific CD8 + T cells recover a subset of memory-related transcriptome features. Yet their unique open chromatin landscape largely reflects an exhausted or dysfunctional state, limiting their protective memory potential.

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Bibliographische Detailangaben
Veröffentlicht in:Nature immunology 2021-08, Vol.22 (8), p.938-940
Hauptverfasser: Yousif, Amir, Ghoneim, Hazem E.
Format: Artikel
Sprache:eng
Schlagworte:
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Antigens
Biomedical and Life Sciences
Biomedicine
CD8 antigen
CD8 lymphocytes
Chromatin
Development and progression
DNA methylation
Epigenetic inheritance
Epigenetics
Gene expression
Genetic aspects
Health aspects
Hepatitis C
Immunologic memory
Immunological memory
Immunology
Infections
Infectious Diseases
Lymphocytes
Lymphocytes T
Memory cells
News & Views
news-and-views
Scars
T cell receptors
Transcriptomes
Virus diseases
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Beschreibung
Zusammenfassung:Following clearance of chronic infections, virus-specific CD8 + T cells recover a subset of memory-related transcriptome features. Yet their unique open chromatin landscape largely reflects an exhausted or dysfunctional state, limiting their protective memory potential.
ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-021-00977-3