EGFRvIII peptide nanocapsules and bevacizumab nanocapsules: a nose-to-brain multitarget approach against glioblastoma

To evaluate the antitumor efficacy of bevacizumab-functionalized nanocapsules in a rat glioblastoma model after the pretreatment with nanocapsules functionalized with a peptide-specific to the epidermal growth factor receptor variant III. Nanocapsules were prepared, physicochemical characterized and...

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Veröffentlicht in:Nanomedicine (London, England) England), 2021-08, Vol.16 (20), p.1775-1790
Hauptverfasser: de Cristo Soares Alves, Aline, Lavayen, Vladimir, de Fraga Dias, Amanda, Bruinsmann, Franciele Aline, Scholl, Juliete Nathali, Cé, Rodrigo, Visioli, Fernanda, Oliveira Battastini, Ana Maria, Stanisçuaski Guterres, Silvia, Figueiró, Fabrício, Raffin Pohlmann, Adriana
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Sprache:eng
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Zusammenfassung:To evaluate the antitumor efficacy of bevacizumab-functionalized nanocapsules in a rat glioblastoma model after the pretreatment with nanocapsules functionalized with a peptide-specific to the epidermal growth factor receptor variant III. Nanocapsules were prepared, physicochemical characterized and intranasally administered to rats. Parameters such as tumor size, histopathological characteristics and infiltration of CD8 T lymphocytes were evaluated. The strategy of treatment resulted in a reduction of 87% in the tumor size compared with the control group and a higher infiltration of CD8 T lymphocytes in tumoral tissue. The block of two different molecular targets using nose-to-brain delivery represents a new and promising approach against glioblastoma.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2021-0169