GSH-resistant and highly cytoselective ruthenium(II)- p -cymene-(imidazo[4,5- f ][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents

GSH-resistant and highly cytoselective ruthenium(II)- p -cymene-(imidazo[4,5- f ][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents

To avoid the side effects of the current popular platinum-based anticancer drugs, researchers have made tireless attempts to design appropriate GSH-resistant Ru(ii)-arene complexes. In this regard, luminescent ruthenium(ii)-p-cymene-imidazophenanthroline complexes were developed as promising highly...

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Veröffentlicht in:Dalton transactions : an international journal of inorganic chemistry 2021-08, Vol.50 (30), p.10369-10373
Hauptverfasser: Kar, Binoy, Das, Utpal, De, Sourav, Pete, Sudhindra, Sharma S, Ajay, Roy, Nilmadhab, S K, Ashok Kumar, Panda, Debashis, Paira, Priyankar
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biological computing
Caco-2 Cells
Cancer
Cell Survival - drug effects
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Cymenes - chemistry
Cymenes - pharmacology
Drug Resistance, Neoplasm - drug effects
Drug Screening Assays, Antitumor
Glutathione - chemistry
HeLa Cells
Humans
Imidazoles - chemistry
Imidazoles - pharmacology
Monoterpenes - chemistry
Monoterpenes - pharmacology
Phenanthrolines - chemistry
Phenanthrolines - pharmacology
Phenols - chemistry
Phenols - pharmacology
Ruthenium - chemistry
Ruthenium - pharmacology
Ruthenium compounds
Side effects
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Beschreibung
Zusammenfassung:To avoid the side effects of the current popular platinum-based anticancer drugs, researchers have made tireless attempts to design appropriate GSH-resistant Ru(ii)-arene complexes. In this regard, luminescent ruthenium(ii)-p-cymene-imidazophenanthroline complexes were developed as promising highly cytoselective cancer theraputic agents for HeLa and Caco-2 cells.
ISSN:1477-9226
1477-9234
1477-9234
DOI:10.1039/d1dt01604k