In vivo biological safety study of porous zinc oxide/hydroxyapatite composite materials
To evaluate the biological safety of porous zinc oxide (ZnO)/hydroxyapatite (HA) composite materials. The porous ZnO/HA composite materials and porous HA materials were prepared by the spark plasma sintering technology. First, the materials were characterized, including scanning electron microscopy...
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Veröffentlicht in: | Zhongguo xiu fu chong jian wai ke za zhi 2021-07, Vol.35 (7), p.847 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | chi |
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Zusammenfassung: | To evaluate the
biological safety of porous zinc oxide (ZnO)/hydroxyapatite (HA) composite materials.
The porous ZnO/HA composite materials and porous HA materials were prepared by the spark plasma sintering technology. First, the materials were characterized, including scanning electron microscopy to observe the material structure,
degradation experiments to detect the degradation rate of the materials, and inductively coupled plasma emission spectrometer to detect the concentration of Zn
dissolved out of the composite material degradation. Then the two kinds of material extracts were prepared for acute systemic toxicity test. Fifteen male Kunming mice were randomly divided into groups A, B, and C (
=5) and injected intraperitoneally with normal saline, HA extracts, and ZnO/HA extracts, respectively. The body mass of the mice was recorded before injection and at 24, 48, and 72 hours after injection. The liver and kidney tissues were taken at 72 hours for HE staining to evaluate the safety of the composite ma |
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ISSN: | 1002-1892 |
DOI: | 10.7507/1002-1892.202101123 |