Predicting 3D protein structures in light of evolution

Predicting 3D protein structures in light of evolution

Recent advances in AI-based 3D protein structure prediction could help address health-related questions, but may also have far-reaching implications for evolution. Here we discuss the advantages and limitations of high-quality 3D structural predictions by AlphaFold2 in unravelling the relationship b...

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Veröffentlicht in:Nature ecology & evolution 2021-09, Vol.5 (9), p.1195-1198
Hauptverfasser: Bershtein, Shimon, Kleiner, Daniel, Mishmar, Dan
Format: Artikel
Sprache:eng
Schlagworte:
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Biological and Physical Anthropology
Biomedical and Life Sciences
Comment
Ecology
Evolution
Evolutionary Biology
Life Sciences
Paleontology
Predictions
Protein structure
Proteins
Structure-function relationships
Zoology
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Zusammenfassung:Recent advances in AI-based 3D protein structure prediction could help address health-related questions, but may also have far-reaching implications for evolution. Here we discuss the advantages and limitations of high-quality 3D structural predictions by AlphaFold2 in unravelling the relationship between protein properties and their impact on fitness, and emphasize the need to integrate in silico structural predictions with functional genomic studies.
ISSN:2397-334X
2397-334X
DOI:10.1038/s41559-021-01519-8