Production of wheat germ oil containing multilayer hydrogel dressing

A composite wound dressing has been developed by combining different layers consisting of polymers and textiles. Wheat germ oil (WGO) loaded hydrogels have successfully formed on textile nonwovens by cross-linking sodium alginate (SA) with poly(ethylene glycol) diglycidyl ether (PEGDGE). Following freeze-drying, textile-hydrogel composites have been examined according to their physical properties, pH, fluid handling capacity, water vapour permeability, morphology, chemical structure, and cytotoxicity. Hydrogels containing WGO swelled less than pristine hydrogels. Samples with 1% WGO and no WGO showed swelling of 5.9 and 10.5 g/g after 8 h. WGO inclusion resulted in reduced, but more stable fluid handling properties, with more uniform pore distribution (100–200 μm). Moreover, the proliferation of NIH/3T3 cells significantly improved with 1% WGO contained hydrogels. Also, commercial self-adhesive dressings that secure the hydrogels to the wound area were investigated regarding transfer properties. The proposed product demonstrated 8.05 cm3/cm2/s and 541.37 g/m2/day air and water vapour permeability. [Display omitted] •Alginate hydrogels with PEGDGE cross-linking are suitable for industrial production.•The multilayer dressing consists of an absorbent layer and a self-adhesive layer.•Textile nonwoven serves as mechanical support for soft absorbent hydrogel layer.•WGO addition limited swell and transfer features yet increased the fluid stability.•Hydrogels with WGO, induced NIH/3T3 cell proliferation in a dose-dependent manner.