Changes in the prognostic values of modern cardiovascular biomarkers in relation to duration of diabetes mellitus

Based on the complex pathophysiology of type 2 diabetes and atherosclerosis we hypothesized a dynamic change in prognostic value of cardiovascular biomarkers over time. In this prospective study 746 patients with type 2 diabetes mellitus, being followed up for 60 months were analysed. The primary en...

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Veröffentlicht in:	Journal of diabetes and its complications 2021-09, Vol.35 (9), p.107990-107990, Article 107990
Hauptverfasser:	Resl, M., Vila, G., Heinzl, M., Luger, A., Neuhold, S., Prager, R., Wurm, R., Hülsmann, M., Clodi, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biomarkers - blood Cardiovascular disease Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular risk prediction Creatinine Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology Growth Differentiation Factor 15 - blood Heart failure Hospitalization Humans Laboratories Medical prognosis Mortality Natriuretic Peptide, Brain - blood Pathophysiology Patients Peptide Fragments Prognosis Prospective Studies Risk factors Time Factors Troponin T - blood
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Zusammenfassung:	Based on the complex pathophysiology of type 2 diabetes and atherosclerosis we hypothesized a dynamic change in prognostic value of cardiovascular biomarkers over time. In this prospective study 746 patients with type 2 diabetes mellitus, being followed up for 60 months were analysed. The primary endpoint was defined as unplanned hospitalization for cardiovascular disease or death. Beside others, especially the prognostic performance of the biomarkers of interest (GDF-15, NT-proBNP, hs-TnT) was evaluated in relation to quartiles of diabetes duration. In patients having a diabetes duration below 7 years lnGDF-15 (HR 2.84; p
ISSN:	1056-8727 1873-460X
DOI:	10.1016/j.jdiacomp.2021.107990