Hypermethylation of Genes in New Long Noncoding RNA in Ovarian Tumors and Metastases: A Dual Effect

The role of methylation in the regulation of genes of long noncoding RNA (lncRNA) is still poorly understood. We revealed new hypermethylated lncRNA genes in ovarian tumors and their effect on metastasis of ovarian cancer. A multiple and significant ( p

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Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2021-07, Vol.171 (3), p.370-374
Hauptverfasser:	Burdennyy, A. M., Filippova, E. A., Ivanova, N. A., Lukina, S. S., Pronina, I. V., Loginov, V. I., Fridman, M. V., Kazubskaya, T. P., Utkin, D. O., Braga, E. A., Kushlinskii, N. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense RNA Biomedical and Life Sciences Biomedicine Cancer Carcinoma, Endometrioid - diagnosis Carcinoma, Endometrioid - genetics Carcinoma, Endometrioid - metabolism Carcinoma, Endometrioid - secondary Cell Biology Comparative analysis Cystadenocarcinoma, Serous - diagnosis Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - metabolism Cystadenocarcinoma, Serous - secondary Development and progression DNA Methylation Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic Gene regulation Genes Genetic aspects Health aspects Humans Internal Medicine Laboratory Medicine Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mesenchyme Metastases Metastasis Methylation Neoplasm Grading Neoplasm Staging Ovarian cancer Ovarian Neoplasms - diagnosis Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pathology Peritoneal Neoplasms - diagnosis Peritoneal Neoplasms - genetics Peritoneal Neoplasms - metabolism Peritoneal Neoplasms - secondary Peritoneum Reversion RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Semaphorins - genetics Semaphorins - metabolism Stem cells Tumors
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Beschreibung
Zusammenfassung:	The role of methylation in the regulation of genes of long noncoding RNA (lncRNA) is still poorly understood. We revealed new hypermethylated lncRNA genes in ovarian tumors and their effect on metastasis of ovarian cancer. A multiple and significant ( p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-021-05230-3