Impairment of caprine oocyte maturation in vitro and alteration of granulosa cells functions by widely used fungicide mancozeb

Mancozeb is classified as an endocrine disruptor; thus the present study was carried out to investigate the impact of mancozeb on mammalian ovarian functions using in vitro caprine oocyte maturation and granulosa cell culture models. Caprine cumulus oocyte complexes (COCs) and granulosa cells were c...

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Veröffentlicht in:	Tropical animal health and production 2021-07, Vol.53 (3), p.406-406, Article 406
Hauptverfasser:	Dinisri, Ishani, Kodikara, Sandarenu, Prasadani, Madhusha, Pathirana, Indunil, Rathnayake, Chathura, Alexander, Basil, Lee, Kai-Fai, Kodithuwakku, Suranga Pradeep
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Cell culture Cell morphology Cell viability Culture media Cytology Endocrine disruptors Fertilization Fungicides Gametocytes Granulosa cells Life Sciences Luteinizing hormone Mancozeb Maturation Metaphase Morphology Oocytes Ovulation Progesterone Reduction Regular Articles Reproductive status Secretion Veterinary Medicine/Veterinary Science Zoology
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Zusammenfassung:	Mancozeb is classified as an endocrine disruptor; thus the present study was carried out to investigate the impact of mancozeb on mammalian ovarian functions using in vitro caprine oocyte maturation and granulosa cell culture models. Caprine cumulus oocyte complexes (COCs) and granulosa cells were cultured under standard culture conditions and treated with mancozeb concentrations of 0.3, 3, and 30 μg/ml along with a control for 24 h and assessed. Granulosa cell viability and progesterone concentration in spent culture media after treatments were also assessed. Mancozeb significantly decreased ( P
ISSN:	0049-4747 1573-7438
DOI:	10.1007/s11250-021-02854-5