Single-dose yellow fever vaccination is well tolerated in egg-allergic children despite positive intradermal test to the vaccine

Patients were diagnosed with egg allergy if they had a clinical history of reaction after egg ingestion and a positive confirmation test such as a positive skin prick test (SPT) (mean wheal diameter >3 mm or greater than the negative control) or an egg white specific IgE >0.35 kUA/L (Tables E1 and E2, available in this article’s Online Repository at www.jaci-inpractice.org). Future larger studies are required to better characterize the diagnostic performance of the YF ID test, but, overall, its diagnostic accuracy appears to be very poor in our population. [...]parents are often reluctant to accept repeated invasive procedures for treatment of their children, as is the case with YF vaccine, which can be associated with significant discomfort. [...]because of the study’s timeframe, the YF vaccine lots were different, and the egg protein content of these vaccines was not determined. [...]YF vaccination in egg-allergic patients could be safe, even with a 1-step protocol.