MiR-592 activates the mTOR kinase, ERK1/ERK2 kinase signaling and imparts neuronal differentiation signature characteristic of Group 4 medulloblastoma

Abstract Medulloblastoma, a common malignant brain tumor in children, consists of four molecular subgroups WNT, SHH, Group 3 and Group 4. Group 3, Group 4 tumors have an overlap in their expression profiles and genetic alterations but differ significantly in their clinical characteristics, with Grou...

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Veröffentlicht in:	Human molecular genetics 2021-11, Vol.30 (24), p.2416-2428
Hauptverfasser:	Paul, Raikamal, Bapat, Purna, Deogharkar, Akash, Kazi, Sadaf, Singh, Satish Kumar Vishram, Gupta, Tejpal, Jalali, Rakesh, Sridhar, Epari, Moiyadi, Aliasgar, Shetty, Prakash, Shirsat, Neelam Vishwanath
Format:	Artikel
Sprache:	eng
Schlagworte:	Cerebellar Neoplasms - genetics Cerebellar Neoplasms - metabolism Child Humans Intracellular Signaling Peptides and Proteins - metabolism Medulloblastoma - genetics Medulloblastoma - metabolism Medulloblastoma - pathology MicroRNAs - genetics Mitogen-Activated Protein Kinase 3 - metabolism Signal Transduction - genetics TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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Zusammenfassung:	Abstract Medulloblastoma, a common malignant brain tumor in children, consists of four molecular subgroups WNT, SHH, Group 3 and Group 4. Group 3, Group 4 tumors have an overlap in their expression profiles and genetic alterations but differ significantly in their clinical characteristics, with Group 3 having the worst 5-year overall survival of
ISSN:	0964-6906 1460-2083
DOI:	10.1093/hmg/ddab201