1'-Acetoxychavicol acetate, a potent transient receptor potential ankyrin 1 agonist derived from Thai ginger, prevents visceral fat accumulation in mice fed with a high-fat and high-sucrose diet
1'-Acetoxychavicol acetate (ACA) is found in Thai ginger (Alpinia galanga) and is a powerful agonist of transient receptor potential ankyrin 1 (TRPA1). In a diet-induced obesity mouse model, ACA reduced fat deposition. Sympathetic nerve activation was also indicated in the ACA-fed group. This s...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2021-09, Vol.85 (10), p.2191-2194 |
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| container_end_page | 2194 |
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| container_issue | 10 |
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| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 85 |
| creator | Ikeya, Tatsunori Terada, Yuko Morimitsu, Yasujiro Kubota, Kikue Ito, Keisuke Watanabe, Tatsuo |
| description | 1'-Acetoxychavicol acetate (ACA) is found in Thai ginger (Alpinia galanga) and is a powerful agonist of transient receptor potential ankyrin 1 (TRPA1). In a diet-induced obesity mouse model, ACA reduced fat deposition. Sympathetic nerve activation was also indicated in the ACA-fed group. This study is expected to promote the utilization of food containing TRPA1 agonists to treat obesity. |
| doi_str_mv | 10.1093/bbb/zbab131 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1347-6947 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2021-09, Vol.85 (10), p.2191-2194 |
| issn | 1347-6947 1347-6947 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2553235038 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Benzyl Alcohols - pharmacology Diet, High-Fat - adverse effects Dietary Sucrose Intra-Abdominal Fat - drug effects Intra-Abdominal Fat - metabolism Male Mice Mice, Inbred C57BL Obesity - drug therapy Obesity - metabolism TRPA1 Cation Channel - agonists TRPA1 Cation Channel - metabolism Zingiber officinale - chemistry |
| title | 1'-Acetoxychavicol acetate, a potent transient receptor potential ankyrin 1 agonist derived from Thai ginger, prevents visceral fat accumulation in mice fed with a high-fat and high-sucrose diet |
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