1'-Acetoxychavicol acetate, a potent transient receptor potential ankyrin 1 agonist derived from Thai ginger, prevents visceral fat accumulation in mice fed with a high-fat and high-sucrose diet

1'-Acetoxychavicol acetate, a potent transient receptor potential ankyrin 1 agonist derived from Thai ginger, prevents visceral fat accumulation in mice fed with a high-fat and high-sucrose diet

1'-Acetoxychavicol acetate (ACA) is found in Thai ginger (Alpinia galanga) and is a powerful agonist of transient receptor potential ankyrin 1 (TRPA1). In a diet-induced obesity mouse model, ACA reduced fat deposition. Sympathetic nerve activation was also indicated in the ACA-fed group. This s...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2021-09, Vol.85 (10), p.2191-2194
Hauptverfasser: Ikeya, Tatsunori, Terada, Yuko, Morimitsu, Yasujiro, Kubota, Kikue, Ito, Keisuke, Watanabe, Tatsuo
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Benzyl Alcohols - pharmacology
Diet, High-Fat - adverse effects
Dietary Sucrose
Intra-Abdominal Fat - drug effects
Intra-Abdominal Fat - metabolism
Male
Mice
Mice, Inbred C57BL
Obesity - drug therapy
Obesity - metabolism
TRPA1 Cation Channel - agonists
TRPA1 Cation Channel - metabolism
Zingiber officinale - chemistry
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Zusammenfassung:1'-Acetoxychavicol acetate (ACA) is found in Thai ginger (Alpinia galanga) and is a powerful agonist of transient receptor potential ankyrin 1 (TRPA1). In a diet-induced obesity mouse model, ACA reduced fat deposition. Sympathetic nerve activation was also indicated in the ACA-fed group. This study is expected to promote the utilization of food containing TRPA1 agonists to treat obesity.
ISSN:1347-6947
1347-6947
DOI:10.1093/bbb/zbab131