B(C 6 F 5 ) 3 -Catalyzed Highly Chemoselective Reduction of Isatins: Synthesis of Indolin-3-ones and Indolines
A chemo- and site-selective reduction reaction of isatin derivatives using catalyst B(C₆F₅)₃ and hydrosilanes is described. This transformation is operationally simple, proceeds under mild conditions, and is resistant to various functional groups. Thus, this efficient reaction using a combination of...
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Veröffentlicht in: | Organic letters 2020-10, Vol.22 (20), p.8150-8155 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A chemo- and site-selective reduction reaction of isatin derivatives using catalyst B(C₆F₅)₃ and hydrosilanes is described. This transformation is operationally simple, proceeds under mild conditions, and is resistant to various functional groups. Thus, this efficient reaction using a combination of B(C₆F₅)₃ and BnMe₂SiH or B(C₆F₅)₃ and Et₂SiH₂ could potentially be utilized to produce various indolin-3-ones and indolines, without the need for multistep procedures and metal catalysis conditions. |
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ISSN: | 1523-7060 1523-7052 1523-7052 |
DOI: | 10.1021/acs.orglett.0c03150 |