B(C 6 F 5 ) 3 -Catalyzed Highly Chemoselective Reduction of Isatins: Synthesis of Indolin-3-ones and Indolines

A chemo- and site-selective reduction reaction of isatin derivatives using catalyst B(C₆F₅)₃ and hydrosilanes is described. This transformation is operationally simple, proceeds under mild conditions, and is resistant to various functional groups. Thus, this efficient reaction using a combination of...

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Veröffentlicht in:Organic letters 2020-10, Vol.22 (20), p.8150-8155
Hauptverfasser: Jeong, Hyojin, Han, Nara, Hwang, Dong Wook, Ko, Haye Min
Format: Artikel
Sprache:eng
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Zusammenfassung:A chemo- and site-selective reduction reaction of isatin derivatives using catalyst B(C₆F₅)₃ and hydrosilanes is described. This transformation is operationally simple, proceeds under mild conditions, and is resistant to various functional groups. Thus, this efficient reaction using a combination of B(C₆F₅)₃ and BnMe₂SiH or B(C₆F₅)₃ and Et₂SiH₂ could potentially be utilized to produce various indolin-3-ones and indolines, without the need for multistep procedures and metal catalysis conditions.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.0c03150