Enantioselective Synthesis of Chiral Substituted 2,4-Diketoimidazolidines and 2,5-Diketopiperazines via Asymmetric Hydrogenation

Enantioselective Synthesis of Chiral Substituted 2,4-Diketoimidazolidines and 2,5-Diketopiperazines via Asymmetric Hydrogenation

An enantioselective hydrogenation of 5-alkylidene-2,4-diketoimidazolidines (hydantoins) and 3-alkylidene-2,5-ketopiperazines catalyzed by the Rh/f-spiroPhos complex under mild conditions has been developed, which provides an efficient approach to the highly enantioselective synthesis of chiral hydan...

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Veröffentlicht in:Organic letters 2021-08, Vol.23 (15), p.5734-5738
Hauptverfasser: Xiao, Guiying, Xu, Shuang, Xie, Chaochao, Zi, Guofu, Ye, Weiping, Zhou, Zhangtao, Hou, Guohua, Zhang, Zhanbin
Format: Artikel
Sprache:eng
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Zusammenfassung:An enantioselective hydrogenation of 5-alkylidene-2,4-diketoimidazolidines (hydantoins) and 3-alkylidene-2,5-ketopiperazines catalyzed by the Rh/f-spiroPhos complex under mild conditions has been developed, which provides an efficient approach to the highly enantioselective synthesis of chiral hydantoins and 2,5-ketopiperazine derivatives with high enantioselectivities up to 99.9% ee.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c01894