Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth

Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, and patients that develop metastases (~50%) survive

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Veröffentlicht in:	Oncogene 2021-08, Vol.40 (33), p.5182-5191
Hauptverfasser:	Kaluz, Stefan, Zhang, Qing, Kuranaga, Yuki, Yang, Hua, Osuka, Satoru, Bhattacharya, Debanjan, Devi, Narra S., Mun, Jiyoung, Wang, Wei, Zhang, Ruiwen, Goodman, Mark M., Grossniklaus, Hans E., Van Meir, Erwin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/109 13/51 38/39 631/67 631/67/70 64 64/60 82 82/80 Animals Apoptosis Biochemistry & Molecular Biology Cancer Care and treatment Cell Biology Cell Line, Tumor Cell Proliferation Collagen Collagen - metabolism Development and progression Extracellular matrix Eye cancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genetics & Heredity Health aspects Human Genetics Humans Hydroxylase Hydroxylases Hydroxylation Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Internal Medicine Life Sciences & Biomedicine Malignancy Medical prognosis Medicine Medicine & Public Health Melanoma Melanoma - genetics Melanoma - metabolism Melanoma - pathology Metastases Metastasis Mice Molecular targeted therapy Neoplasm Metastasis Oncology Oncology, Experimental Patients Procollagen-proline dioxygenase Procollagen-Proline Dioxygenase - genetics Procollagen-Proline Dioxygenase - metabolism Prognosis Prolyl Hydroxylases Proteolysis Science & Technology Transcription factors Uvea Uveal Neoplasms - genetics Uveal Neoplasms - metabolism Uveal Neoplasms - pathology Xenograft Model Antitumor Assays
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Zusammenfassung:	Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, and patients that develop metastases (~50%) survive
ISSN:	0950-9232 1476-5594 1476-5594
DOI:	10.1038/s41388-021-01919-x