Ocular manifestations of anti-neoplastic immune checkpoint inhibitor-associated Stevens-Johnson syndrome/toxic epidermal necrolysis in cancer patients

•SJS/TEN with severe ocular involvement can occur following immune checkpoint inhibitor treatment.•Causative ICIs included nivolumab, pembrolizumab, atezolizumab, durvalumab, and ipilimumab.•Poor survival of the patients due to advanced cancer stage.•Early and aggressive treatments are vital to prev...

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Veröffentlicht in:	The ocular surface 2021-10, Vol.22, p.47-50
Hauptverfasser:	Ma, Kevin Sheng-Kai, Saeed, Hajirah N., Chodosh, James, Wang, Chuang-Wei, Chung, Yu-Chien, Wei, Li-Chen, Kuo, Ming-Tse, Liang, Chang-Min, Chang, John Wen-Cheng, Chung, Wen-Hung, Chen, Chun-Bing, Ma, David Hui-Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithm of drug causality for epidermal necrolysis Eye Humans Immune checkpoint inhibitor Immune Checkpoint Inhibitors Neoplasms Ocular surface grading score Stevens-Johnson syndrome Stevens-Johnson Syndrome - etiology Toxic epidermal necrolysis
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Beschreibung
Zusammenfassung:	•SJS/TEN with severe ocular involvement can occur following immune checkpoint inhibitor treatment.•Causative ICIs included nivolumab, pembrolizumab, atezolizumab, durvalumab, and ipilimumab.•Poor survival of the patients due to advanced cancer stage.•Early and aggressive treatments are vital to prevent long-term ocular complication.
ISSN:	1542-0124 1937-5913
DOI:	10.1016/j.jtos.2021.06.010