Systematic review and meta-analyses of vitamin E (alpha-tocopherol) supplementation and blood lipid parameters in patients with diabetes mellitus

The studies have shown that α-tocopherol supplementation could improve lipid profile in diabetes mellitus (DM) patients. Nonetheless, the result remains inconsistent. Therefore, this meta-analysis was performed to evaluate the efficacy of α-tocopherol supplement on lipid parameters in DM patients. We conducted an extensive search via Cochrane Library, PubMed, Scopus, and Web of Science databases to acquire the reported RCTs up to October 2020. The results showed no effects of α-tocopherol supplementation on lipid profile in DM patients except when used ≥12 weeks. α-tocopherol supplementation in DM patients had no significant effect on lipid profiles. •α-tocopherol supplementation may be a useful factor in improving cardiovascular risk factors in patients with diabetes.•α-tocopherol supplementation did not affect blood lipid parameters in patients with diabetes.•α-tocopherol supplementation may improve TC and HDL-C levels when supplemented for ≥12 week duration.